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Literature DB >> 18489165

A facile route to 2,4-dihydro-1H-benzo[d][1,3]thiazines via silver-catalyzed tandem addition-cyclization reactions.

Abstract

Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isothiocyanates catalyzed by silver triflate are described; they provide an efficient and practical route for the synthesis of 2,4-dihydro-1 H-benzo[ d][1,3]thiazines.

Entities: Chemical

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Year: 2008 PMID： 18489165 DOI： 10.1021/cc800043r

Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766

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Cited

5 in total

1. Cinnoline derivatives as human neutrophil elastase inhibitors.

Authors: Maria Paola Giovannoni; Igor A Schepetkin; Letizia Crocetti; Giovanna Ciciani; Agostino Cilibrizzi; Gabriella Guerrini; Andrei I Khlebnikov; Mark T Quinn; Claudia Vergelli
Journal: J Enzyme Inhib Med Chem Date: 2015-07-21 Impact factor: 5.051

2. Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent.

Authors: Venkat R Pallela; Muralidhar R Mallireddigari; Stephen C Cosenza; Balaiah Akula; D R C Venkata Subbaiah; E Premkumar Reddy; M V Ramana Reddy
Journal: Org Biomol Chem Date: 2013-02-06 Impact factor: 3.876

A facile route to 2,4-dihydro-1H-benzo[d][1,3]thiazines via silver-catalyzed tandem addition-cyclization reactions.

1. Cinnoline derivatives as human neutrophil elastase inhibitors.

2. Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent.

3. Pd(II)-catalyzed ortho arylation of 2-arylbenzothiazoles with aryl iodides via benzothiazole-directed C-H activation.

4. From Thioureas to Thioquinolines through Isolated Benzothiazines by Gold Catalysis.

5. Gold-Catalyzed 1,3-Thiazine Formation and Uncommon Tautomer Isolation.