| Literature DB >> 18489103 |
Lynda J Brown1, Ian B Spurr, Stephen C Kemp, Nicholas P Camp, Karl R Gibson, Richard C D Brown.
Abstract
An asymmetric total synthesis of (+)-cis-sylvaticin is described. Key steps include the use of permanganate-mediated oxidative cyclization of 1,5-dienes to synthesize the two major fragments 2 and 3 and a catalytically efficient tethered RCM to unite these THF-containing fragments. In addition, t-BuP 4 base was found to reliably promote rapid alkylation of the butenolide precursor fragment 4.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18489103 DOI： 10.1021/ol800767e
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005