Literature DB >> 18488022

Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions.

Hirotaka Sakamoto1, Ken-Ichi Matsuda, Damian G Zuloaga, Hisayuki Hongu, Etsuko Wada, Keiji Wada, Cynthia L Jordan, S Marc Breedlove, Mitsuhiro Kawata.   

Abstract

Neurons in the upper lumbar spinal cord project axons containing gastrin-releasing peptide (GRP) to innervate lower lumbar regions controlling erection and ejaculation. This system is vestigial in female rats and in males with genetic dysfunction of androgen receptors, but in male rats, pharmacological stimulation of spinal GRP receptors restores penile reflexes and ejaculation after castration. GRP offers new avenues for understanding potential therapeutic approaches to masculine reproductive dysfunction.

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Year:  2008        PMID： 18488022      PMCID： PMC3954789          DOI： 10.1038/nn.2126

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  14 in total

1.  The neurobiology of sexual function.

Authors:  C M Meston; P F Frohlich
Journal:  Arch Gen Psychiatry       Date:  2000-11

2.  Identification of a potential ejaculation generator in the spinal cord.

Authors:  William A Truitt; Lique M Coolen
Journal:  Science       Date:  2002-08-30       Impact factor: 47.728

3.  Increased expression of neuronal nitric oxide synthase (NOS) in visceral neurons after nerve injury.

Authors:  M A Vizzard; S L Erdman; W C de Groat
Journal:  J Neurosci       Date:  1995-05       Impact factor: 6.167

Review 4.  Two distinct receptor subtypes for mammalian bombesin-like peptides.

Authors:  J Battey; E Wada
Journal:  Trends Neurosci       Date:  1991-12       Impact factor: 13.837

5.  Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes.

Authors:  A Anastasi; V Erspamer; M Bucci
Journal:  Experientia       Date:  1971-02-15

6.  The distribution of visceral primary afferents from the pelvic nerve to Lissauer's tract and the spinal gray matter and its relationship to the sacral parasympathetic nucleus.

Authors:  C Morgan; I Nadelhaft; W C de Groat
Journal:  J Comp Neurol       Date:  1981-09-20       Impact factor: 3.215

7.  Bombesin/gastrin-releasing peptide receptors in the basolateral amygdala regulate memory consolidation.

Authors:  Rafael Roesler; Daniela Lessa; Roberta Venturella; Mônica R M Vianna; Tatiana Luft; João Antônio Pegas Henriques; Ivan Izquierdo; Gilberto Schwartsmann
Journal:  Eur J Neurosci       Date:  2004-02       Impact factor: 3.386

8.  Photic regulation of peptides located in the ventrolateral subdivision of the suprachiasmatic nucleus of the rat: daily variations of vasoactive intestinal polypeptide, gastrin-releasing peptide, and neuropeptide Y.

Authors:  K Shinohara; K Tominaga; Y Isobe; S T Inouye
Journal:  J Neurosci       Date:  1993-02       Impact factor: 6.167

9.  Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear.

Authors:  Gleb P Shumyatsky; Evgeny Tsvetkov; Gaël Malleret; Svetlana Vronskaya; Michael Hatton; Lori Hampton; James F Battey; Catherine Dulac; Eric R Kandel; Vadim Y Bolshakov
Journal:  Cell       Date:  2002-12-13       Impact factor: 41.582

Review 10.  International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.

Authors:  R T Jensen; J F Battey; E R Spindel; R V Benya
Journal:  Pharmacol Rev       Date:  2007-11-30       Impact factor: 25.468
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  29 in total

1.  Three-dimensional evaluation of the spinal local neural network revealed by the high-voltage electron microscopy: a double immunohistochemical study.

Authors:  Takumi Oti; Keita Satoh; Kazuhiro Saito; Kazuyoshi Murata; Mitsuhiro Kawata; Tatsuya Sakamoto; Hirotaka Sakamoto
Journal:  Histochem Cell Biol       Date:  2012-06-12       Impact factor: 4.304

2.  Rhythmic motor patterns accompanying ejaculation in spinal cord-transected male rats.

Authors:  M Carro-Juárez; G Rodríguez-Manzo; M de Lourdes Rodríguez Peña; M Á Franco
Journal:  Int J Impot Res       Date:  2014-02-20       Impact factor: 2.896

3.  Chronic Spinal Cord Injury Reduces Gastrin-Releasing Peptide in the Spinal Ejaculation Generator in Male Rats.

Authors:  J Walker Wiggins; Natalie Kozyrev; Jonathan E Sledd; George G Wilson; Lique M Coolen
Journal:  J Neurotrauma       Date:  2019-07-10       Impact factor: 5.269

Review 4.  Spinal Mechanisms of Itch Transmission.

Authors:  Devin M Barry; Admire Munanairi; Zhou-Feng Chen
Journal:  Neurosci Bull       Date:  2017-04-01       Impact factor: 5.203

Review 5.  Impact of androgen deprivation therapy on sexual function.

Authors:  Clarisse R Mazzola; John P Mulhall
Journal:  Asian J Androl       Date:  2012-01-09       Impact factor: 3.285

Review 6.  The organizational hypothesis and final common pathways: Sexual differentiation of the spinal cord and peripheral nervous system.

Authors:  Nancy G Forger
Journal:  Horm Behav       Date:  2009-05       Impact factor: 3.587

7.  Androgen regulates the sexually dimorphic gastrin-releasing peptide system in the lumbar spinal cord that mediates male sexual function.

Authors:  Hirotaka Sakamoto; Keiko Takanami; Damian G Zuloaga; Ken-ichi Matsuda; Cynthia L Jordan; S Marc Breedlove; Mitsuhiro Kawata
Journal:  Endocrinology       Date:  2009-04-09       Impact factor: 4.736

8.  Gastrin-releasing peptide acts via postsynaptic BB2 receptors to modulate inward rectifier K+ and TRPV1-like conductances in rat paraventricular thalamic neurons.

Authors:  M L H J Hermes; M Kolaj; E M Coderre; L P Renaud
Journal:  J Physiol       Date:  2013-01-28       Impact factor: 5.182

Review 9.  The hormonal control of ejaculation.

Authors:  Giovanni Corona; Emmanuele A Jannini; Linda Vignozzi; Giulia Rastrelli; Mario Maggi
Journal:  Nat Rev Urol       Date:  2012-08-07       Impact factor: 14.432

10.  Expression of G protein-coupled receptor 30 in the spinal somatosensory system.

Authors:  Keiko Takanami; Hirotaka Sakamoto; Ken-Ichi Matsuda; Koji Hosokawa; Mayumi Nishi; Eric R Prossnitz; Mitsuhiro Kawata
Journal:  Brain Res       Date:  2009-11-11       Impact factor: 3.252
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