Literature DB >> 18487338

The Burkholderia mallei BmaR3-BmaI3 quorum-sensing system produces and responds to N-3-hydroxy-octanoyl homoserine lactone.

Breck A Duerkop1, Jake P Herman, Ricky L Ulrich, Mair E A Churchill, E Peter Greenberg.   

Abstract

Burkholderia mallei has two acyl-homoserine lactone (acyl-HSL) signal generator-receptor pairs and two additional signal receptors, all of which contribute to virulence. We show that B. mallei produces N-3-hydroxy-octanoyl HSL (3OHC8-HSL) but a bmaI3 mutant does not. Recombinant Escherichia coli expressing BmaI3 produces hydroxylated acyl-HSLs, with 3OHC8-HSL being the most abundant compound. In recombinant E. coli, BmaR3 responds to 3OHC8-HSL but not to other acyl-HSLs. These data indicate that the signal for BmaR3-BmaI3 quorum sensing is 3OHC8-HSL.

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Year:  2008        PMID： 18487338      PMCID： PMC2447019          DOI： 10.1128/JB.00246-08

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  29 in total

Review 1.  Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators.

Authors:  C Fuqua; S C Winans; E P Greenberg
Journal:  Annu Rev Microbiol       Date:  1996       Impact factor: 15.500

Review 2.  Quorum sensing and the cell-cell communication dependent regulation of gene expression in pathogenic and non-pathogenic bacteria.

Authors:  A M Hardman; G S Stewart; P Williams
Journal:  Antonie Van Leeuwenhoek       Date:  1998-11       Impact factor: 2.271

3.  Quorum sensing: a transcriptional regulatory system involved in the pathogenicity of Burkholderia mallei.

Authors:  Ricky L Ulrich; David Deshazer; Harry B Hines; Jeffrey A Jeddeloh
Journal:  Infect Immun       Date:  2004-11       Impact factor: 3.441

4.  Specificity of acyl-homoserine lactone synthases examined by mass spectrometry.

Authors:  Ty A Gould; Jake Herman; Jessica Krank; Robert C Murphy; Mair E A Churchill
Journal:  J Bacteriol       Date:  2006-01       Impact factor: 3.490

5.  Quorum sensing regulates dpsA and the oxidative stress response in Burkholderia pseudomallei.

Authors:  Putthapoom Lumjiaktase; Stephen P Diggle; Suvit Loprasert; Sumalee Tungpradabkul; Mavis Daykin; Miguel Cámara; Paul Williams; Mongkol Kunakorn
Journal:  Microbiology       Date:  2006-12       Impact factor: 2.777

Review 6.  Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing.

Authors:  C Fuqua; M R Parsek; E P Greenberg
Journal:  Annu Rev Genet       Date:  2001       Impact factor: 16.830

7.  Identification of genes and gene products necessary for bacterial bioluminescence.

Authors:  J Engebrecht; M Silverman
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

8.  Transcriptome analysis of the Vibrio fischeri LuxR-LuxI regulon.

Authors:  Luis Caetano M Antunes; Amy L Schaefer; Rosana B R Ferreira; Nan Qin; Ann M Stevens; Edward G Ruby; E Peter Greenberg
Journal:  J Bacteriol       Date:  2007-09-07       Impact factor: 3.490

9.  Inhibition and activation of bacterial luciferase synthesis.

Authors:  A Eberhard
Journal:  J Bacteriol       Date:  1972-03       Impact factor: 3.490

10.  Activation of the Pseudomonas aeruginosa lasI gene by LasR and the Pseudomonas autoinducer PAI: an autoinduction regulatory hierarchy.

Authors:  P C Seed; L Passador; B H Iglewski
Journal:  J Bacteriol       Date:  1995-02       Impact factor: 3.490
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  17 in total

1.  Determinants governing ligand specificity of the Vibrio harveyi LuxN quorum-sensing receptor.

Authors:  Xiaobo Ke; Laura C Miller; Bonnie L Bassler
Journal:  Mol Microbiol       Date:  2014-11-27       Impact factor: 3.501

2.  Defining the structure and function of acyl-homoserine lactone autoinducers.

Authors:  Mair E A Churchill; Hiruy M Sibhatu; Charis L Uhlson
Journal:  Methods Mol Biol       Date:  2011

3.  Enzymatic Assays to Investigate Acyl-Homoserine Lactone Autoinducer Synthases.

Authors:  Daniel Shin; Rajesh Nagarajan
Journal:  Methods Mol Biol       Date:  2018

4.  Burkholderia as a Source of Natural Products.

Authors:  Sylvia Kunakom; Alessandra S Eustáquio
Journal:  J Nat Prod       Date:  2019-07-11       Impact factor: 4.050

Review 5.  Structural basis of acyl-homoserine lactone-dependent signaling.

Authors:  Mair E A Churchill; Lingling Chen
Journal:  Chem Rev       Date:  2010-12-02       Impact factor: 60.622

6.  Cross-species comparison of the Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia mallei quorum-sensing regulons.

Authors:  Charlotte D Majerczyk; Mitchell J Brittnacher; Michael A Jacobs; Christopher D Armour; Matthew C Radey; Richard Bunt; Hillary S Hayden; Ryland Bydalek; E Peter Greenberg
Journal:  J Bacteriol       Date:  2014-09-02       Impact factor: 3.490

7.  Virulence of Burkholderia mallei quorum-sensing mutants.

Authors:  Charlotte Majerczyk; Loren Kinman; Tony Han; Richard Bunt; E Peter Greenberg
Journal:  Infect Immun       Date:  2013-02-19       Impact factor: 3.441

8.  A Burkholderia cenocepacia orphan LuxR homolog is involved in quorum-sensing regulation.

Authors:  Rebecca J Malott; Eoin P O'Grady; Jessica Toller; Silja Inhülsen; Leo Eberl; Pamela A Sokol
Journal:  J Bacteriol       Date:  2009-02-06       Impact factor: 3.490

9.  Pathema: a clade-specific bioinformatics resource center for pathogen research.

Authors:  Lauren M Brinkac; Tanja Davidsen; Erin Beck; Anuradha Ganapathy; Elisabet Caler; Robert J Dodson; A Scott Durkin; Derek M Harkins; Hernan Lorenzi; Ramana Madupu; Yinong Sebastian; Susmita Shrivastava; Mathangi Thiagarajan; Joshua Orvis; Jaideep P Sundaram; Jonathon Crabtree; Kevin Galens; Yongmei Zhao; Jason M Inman; Robert Montgomery; Seth Schobel; Kevin Galinsky; David M Tanenbaum; Adam Resnick; Nikhat Zafar; Owen White; Granger Sutton
Journal:  Nucleic Acids Res       Date:  2009-10-20       Impact factor: 16.971

10.  Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis.

Authors:  Breck A Duerkop; John Varga; Josephine R Chandler; Snow Brook Peterson; Jake P Herman; Mair E A Churchill; Matthew R Parsek; William C Nierman; E Peter Greenberg
Journal:  J Bacteriol       Date:  2009-04-17       Impact factor: 3.490
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