Literature DB >> 18485491

Characterization of ganglionic acetylcholine receptor autoantibodies.

Steven Vernino1, Jon Lindstrom, Steve Hopkins, Zhengbei Wang, Phillip A Low.   

Abstract

In myasthenia gravis (MG), autoantibodies bind to the alpha1 subunit and other subunits of the muscle nicotinic acetylcholine receptor (AChR). Autoimmune autonomic ganglionopathy (AAG) is an antibody-mediated neurological disorder caused by antibodies against neuronal AChRs in autonomic ganglia. Subunits of muscle and neuronal AChR are homologous. We examined the specificity of AChR antibodies in patients with MG and AAG. Ganglionic AChR autoantibodies found in AAG patients are specific for AChRs containing the alpha3 subunit. Muscle and ganglionic AChR antibody specificities are distinct. Antibody crossreactivity between AChRs with different alpha subunits is uncommon but can occur.

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Year:  2008        PMID： 18485491      PMCID： PMC2536520          DOI： 10.1016/j.jneuroim.2008.03.017

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  27 in total

1.  Alpha subunit composition of nicotinic acetylcholine receptors in the rat autonomic ganglia neurons as determined with subunit-specific anti-alpha(181-192) peptide antibodies.

Authors:  M V Skok; L P Voitenko; S V Voitenko; E Y Lykhmus; E N Kalashnik; T I Litvin; S J Tzartos; V I Skok
Journal:  Neuroscience       Date:  1999       Impact factor: 3.590

2.  Megacystis, mydriasis, and ion channel defect in mice lacking the alpha3 neuronal nicotinic acetylcholine receptor.

Authors:  W Xu; S Gelber; A Orr-Urtreger; D Armstrong; R A Lewis; C N Ou; J Patrick; L Role; M De Biasi; A L Beaudet
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

3.  Myasthenia gravis patients, but not healthy subjects, recognize epitopes that are unique to the epsilon-subunit of the acetylcholine receptor.

Authors:  Samia Ragheb; Mahmoud Mohamed; Robert P Lisak
Journal:  J Neuroimmunol       Date:  2004-11-23       Impact factor: 3.478

4.  Plasma exchange for primary autoimmune autonomic failure.

Authors:  Christoph Schroeder; Steven Vernino; Andreas L Birkenfeld; Jens Tank; Karsten Heusser; Axel Lipp; Thomas Benter; Carsten Lindschau; Ralph Kettritz; Friedrich C Luft; Jens Jordan
Journal:  N Engl J Med       Date:  2005-10-13       Impact factor: 91.245

Review 5.  Anatomy of the antigenic structure of a large membrane autoantigen, the muscle-type nicotinic acetylcholine receptor.

Authors:  S J Tzartos; T Barkas; M T Cung; A Mamalaki; M Marraud; P Orlewski; D Papanastasiou; C Sakarellos; M Sakarellos-Daitsiotis; P Tsantili; V Tsikaris
Journal:  Immunol Rev       Date:  1998-06       Impact factor: 12.988

6.  Nicotine acts as a pharmacological chaperone to up-regulate human alpha4beta2 acetylcholine receptors.

Authors:  A Kuryatov; J Luo; J Cooper; J Lindstrom
Journal:  Mol Pharmacol       Date:  2005-09-23       Impact factor: 4.436

Review 7.  Myasthenia gravis.

Authors:  D B Drachman
Journal:  N Engl J Med       Date:  1994-06-23       Impact factor: 91.245

8.  Passive transfer of autoimmune autonomic neuropathy to mice.

Authors:  Steven Vernino; Leonid G Ermilov; Lei Sha; Joseph H Szurszewski; Phillip A Low; Vanda A Lennon
Journal:  J Neurosci       Date:  2004-08-11       Impact factor: 6.167

9.  Neuronal nicotinic ACh receptor antibody in subacute autonomic neuropathy and cancer-related syndromes.

Authors:  S Vernino; J Adamski; T J Kryzer; R D Fealey; V A Lennon
Journal:  Neurology       Date:  1998-06       Impact factor: 9.910

10.  Alpha7-acetylcholine receptor antibodies in two patients with Rasmussen encephalitis.

Authors:  R Watson; J E C Jepson; I Bermudez; S Alexander; Y Hart; K McKnight; A Roubertie; F Fecto; J Valmier; D B Sattelle; D Beeson; A Vincent; B Lang
Journal:  Neurology       Date:  2005-12-13       Impact factor: 9.910
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  23 in total

Review 1.  Mechanisms underlying autoimmune synaptic encephalitis leading to disorders of memory, behavior and cognition: insights from molecular, cellular and synaptic studies.

Authors:  Emilia H Moscato; Ankit Jain; Xiaoyu Peng; Ethan G Hughes; Josep Dalmau; Rita J Balice-Gordon
Journal:  Eur J Neurosci       Date:  2010-07-14       Impact factor: 3.386

2.  Autoimmune autonomic ganglionopathy manifesting as acute-onset orthostatic hypotension in a patient undergoing peritoneal dialysis.

Authors:  Masatoshi Hara; Shunsuke Yamada; Yuuri Nakamura; Hideaki Oka; Taro Kamimura; Shunya Nakane; Kazuhiko Tsuruya; Atsumi Harada
Journal:  CEN Case Rep       Date:  2015-04-23

3.  Mosquitocidal properties of IgG targeting the glutamate-gated chloride channel in three mosquito disease vectors (Diptera: Culicidae).

Authors:  Jacob I Meyers; Meg Gray; Brian D Foy
Journal:  J Exp Biol       Date:  2015-05-15       Impact factor: 3.312

4.  Autoimmune autonomic ganglionopathy with reversible cognitive impairment.

Authors:  Christopher H Gibbons; Justin Centi; Steven Vernino; Roy Freeman
Journal:  Arch Neurol       Date:  2011-12-12

Review 5.  Autonomic ganglia, acetylcholine receptor antibodies, and autoimmune ganglionopathy.

Authors:  Steven Vernino; Steve Hopkins; Zhengbei Wang
Journal:  Auton Neurosci       Date:  2008-10-31       Impact factor: 3.145

6.  Myasthenogenicity of the main immunogenic region.

Authors:  Jon Lindstrom; Jie Luo
Journal:  Ann N Y Acad Sci       Date:  2012-12       Impact factor: 5.691

7.  Coexistent autoimmune autonomic ganglionopathy and myasthenia gravis associated with non-small-cell lung cancer.

Authors:  Amanda C Peltier; Bonnie K Black; Satish R Raj; Peter Donofrio; David Robertson; Italo Biaggioni
Journal:  Muscle Nerve       Date:  2010-03       Impact factor: 3.217

8.  The value of acetylcholine receptor antibody in children with postural tachycardia syndrome.

Authors:  Jiawei Li; Qingyou Zhang; Ying Liao; Chunyu Zhang; Hongjun Hao; Junbao Du
Journal:  Pediatr Cardiol       Date:  2014-08-03       Impact factor: 1.655

9.  Anti-ganglionic AChR antibodies in Japanese patients with motility disorders.

Authors:  Akihiro Mukaino; Hitomi Minami; Hajime Isomoto; Hitomi Hamamoto; Eikichi Ihara; Yasuhiro Maeda; Osamu Higuchi; Tohru Okanishi; Yohei Kokudo; Kazushi Deguchi; Fumisato Sasaki; Toshihito Ueki; Ken-Ya Murata; Takeshi Yoshida; Mistuyo Kinjo; Yoshihiro Ogawa; Akio Ido; Hidenori Matsuo; Kazuhiko Nakao; Shunya Nakane
Journal:  J Gastroenterol       Date:  2018-05-15       Impact factor: 7.527

10.  Autoimmune autonomic ganglionopathy: treatment by plasma exchanges and rituximab.

Authors:  Richard Imrich; Steven Vernino; Basil A Eldadah; Courtney Holmes; David S Goldstein
Journal:  Clin Auton Res       Date:  2009-04-28       Impact factor: 4.435
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