Literature DB >> 1848528

The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor gene.

W J Keir1, C A Kozak, A Chakraborti, R A Deitrich, J M Sikela.   

Abstract

The murine GABAA/benzodiazepine (GABAA/BZ) receptor alpha 1 subunit cDNA has been isolated from a BALB/c mouse brain library and sequenced. The cDNA is 2665 nucleotides long with an open reading frame of 455 amino acids. It shows significant homology to the GABAA receptor alpha 1 subunit cDNA sequences of other species. Excluding deletions, the murine GABAA alpha 1 receptor exhibits 96% nucleotide and 100% amino acid sequence homology to the rat alpha 1 receptor cDNA and over 91% nucleotide and 98% amino acid sequence homology to the bovine and human alpha 1 receptor cDNAs in the protein coding region. This murine cDNA was used to locate the alpha 1 receptor subunit gene, Gabra-1, to murine Chromosome 11 between Il-3 and Rel. This assignment extends proximally the segment of mouse Chromosome 11 with known homology to human chromosome 5.

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Year:  1991        PMID： 1848528     DOI： 10.1016/0888-7543(91)90272-g

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  11 in total

1.  GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons.

Authors:  S Vicini; C Ferguson; K Prybylowski; J Kralic; A L Morrow; G E Homanics
Journal:  J Neurosci       Date:  2001-05-01       Impact factor: 6.167

2.  Localization of the human chromosome 5q genes Gabra-1, Gabrg-2, Il-4, Il-5, and Irf-1 on mouse chromosome 11.

Authors:  M S Buckwalter; A C Lossie; L M Scarlett; S A Camper
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 3.  Mouse chromosome 11.

Authors:  A M Buchberg; M S Buckwalter; S A Camper
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 4.  Mouse chromosome 11.

Authors:  A M Buchberg; J J Moskow; M S Buckwalter; S A Camper
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 5.  An analysis of vertebrate mRNA sequences: intimations of translational control.

Authors:  M Kozak
Journal:  J Cell Biol       Date:  1991-11       Impact factor: 10.539

6.  Localization of three genes expressed in retina on mouse chromosome 11.

Authors:  C A Kozak; M Danciger; C Bowes; M C Adamson; K Palczewski; A S Polans; D B Farber
Journal:  Mamm Genome       Date:  1995-02       Impact factor: 2.957

7.  The α1,α2, and α3 Subunits of GABAA Receptors: Comparison in Seizure-Prone and -Resistant Mice and during Development.

Authors:  Jia Bei Wang; Paulo Kofuji; John C R Fernando; Stephen J Moss; Richard L Huganir; David R Burt
Journal:  J Mol Neurosci       Date:  1992-12       Impact factor: 3.444

8.  Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome.

Authors:  A S Wilcox; J A Warrington; K Gardiner; R Berger; P Whiting; M R Altherr; J J Wasmuth; D Patterson; J M Sikela
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-01       Impact factor: 11.205

Review 9.  Mapping quantitative trait loci for behavioral traits in the mouse.

Authors:  T E Johnson; J C DeFries; P D Markel
Journal:  Behav Genet       Date:  1992-11       Impact factor: 2.805

10.  The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala.

Authors:  Brian J Wiltgen; Bill P Godsil; Zechun Peng; Faysal Saab; Harry L June; Michael L Van Linn; James M Cook; Carolyn R Houser; Tom J O'Dell; Gregg E Homanics; Michael S Fanselow
Journal:  Front Behav Neurosci       Date:  2009-10-20       Impact factor: 3.558
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