| Literature DB >> 18484775 |
Fernando Reyes1, Rogelio Fernández, Alfredo Rodríguez, Santiago Bueno, Carlos de Eguilior, Andrés Francesch, Carmen Cuevas.
Abstract
Two new indolocarbazole alkaloids, 7-oxo-3,8,9-trihydroxystaurosporine (1) and 7-oxo-8,9-dihydroxy-4'-N-demethylstaurosporine (2), were isolated from samples of the marine ascidian Cystodytes solitus. Their structures were determined by a combination of spectroscopic techniques, including (+)-HRMALDITOFMS and 1D and 2D NMR spectroscopy, and comparison with published data for related structures. Both compounds displayed strong cytotoxicity against three human tumor cell lines.Entities:
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Year: 2008 PMID： 18484775 DOI： 10.1021/np700748h
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050