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Literature DB >> 18484565

HPMA copolymer-doxorubicin-gadolinium conjugates: synthesis, characterization, and in vitro evaluation.

Bahar Zarabi¹, Anjan Nan, Jiachen Zhuo, Rao Gullapalli, Hamidreza Ghandehari.

Abstract

This study describes the synthesis, characterization, and in vitro evaluation of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-gadolinium (Gd)-doxorubicin (Dox) conjugates. Copolymers of HPMA were derivatized to incorporate side chains for Gd chelation and Dox conjugation. The conjugates were characterized by their side chain contents, T(1) relaxivity (r(1)), stability, and in vitro cytotoxicity. High stability and relaxivity of these conjugates coupled with low toxicity show their potential for monitoring the in vivo fate of HPMA-based drug delivery systems by magnetic resonance imaging techniques.

Entities: CellLine Chemical Disease Gene Species

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Year: 2008 PMID： 18484565 PMCID： PMC2704051 DOI： 10.1002/mabi.200700290

Source DB: PubMed Journal: Macromol Biosci ISSN： 1616-5187 Impact factor: 4.979

37 in total

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Journal: J Control Release Date: 2000-02-14 Impact factor: 9.776

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Authors: P Caravan; J J Ellison; T J McMurry; R B Lauffer
Journal: Chem Rev Date: 1999-09-08 Impact factor: 60.622

4. Quantitative assays of the amount of diethylenetriaminepentaacetic acid conjugated to water-soluble polymers using isothermal titration calorimetry and colorimetry.

Authors: S Gouin; F M Winnik
Journal: Bioconjug Chem Date: 2001 May-Jun Impact factor: 4.774

5. Synthetic macromolecular drug carriers: biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors.

Authors: M Kissel; P Peschke; V Subr; K Ulbrich; J Schuhmacher; J Debus; E Friedrich
Journal: PDA J Pharm Sci Technol Date: 2001 May-Jun

HPMA copolymer-doxorubicin-gadolinium conjugates: synthesis, characterization, and in vitro evaluation.

1. Approaches and agents for imaging the vascular system.

2. Polymeric drugs based on conjugates of synthetic and natural macromolecules. I. Synthesis and physico-chemical characterisation.

3. Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications.

4. Quantitative assays of the amount of diethylenetriaminepentaacetic acid conjugated to water-soluble polymers using isothermal titration calorimetry and colorimetry.

5. Synthetic macromolecular drug carriers: biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors.

6. The Gd(3+) complex of a fatty acid analogue of DOTP binds to multiple albumin sites with variable water relaxivities.

Review 7. HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action.

8. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes.

Review 9. The dawning era of polymer therapeutics.

Review 10. Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo.

1. Metal-containing and related polymers for biomedical applications.

2. Noninvasive monitoring of HPMA copolymer-RGDfK conjugates by magnetic resonance imaging.

Review 3. Current advances in polymer-based nanotheranostics for cancer treatment and diagnosis.