OBJECTIVE: The aim of this observational study was to evaluate the effects of duloxetine in the treatment of seasonal affective disorder (SAD). PATIENTS AND METHODS: 26 SAD patients were treated with open-label duloxetine 60-120 mg per day over 8 weeks. Ratings included the Structured Interview Guide for the Hamilton Depression Rating Scale (SAD version; SIGH-SAD) and the Clinical Global Impression (CGI). To estimate treatment effects on social functioning in SAD we employed the Social Adaptation Self Evaluation Scale (SASS), the Sheehan Disability Scale (SDS), and assessments of days lost due to illness and days with reduction in productivity. RESULTS: Duloxetine led to a significant improvement (p<0.001) of SIGH-SAD, CGI severity, SASS, and SDS scores. Days lost due to illness and days with reduction in productivity were significantly diminished during treatment (p<0.001). Treatment with duloxetine over 8 weeks yielded a response rate (SIGH-SAD<50% of baseline value) of 80.8% and a remission rate (SIGH-SAD<8) of 76.9% in the intention to treat sample. The drop-out rate due to side effects was 15.4%. CONCLUSIONS: Our preliminary results indicate that duloxetine might be effective and able to ameliorate the negative social consequences of SAD.
OBJECTIVE: The aim of this observational study was to evaluate the effects of duloxetine in the treatment of seasonal affective disorder (SAD). PATIENTS AND METHODS: 26 SADpatients were treated with open-label duloxetine 60-120 mg per day over 8 weeks. Ratings included the Structured Interview Guide for the Hamilton Depression Rating Scale (SAD version; SIGH-SAD) and the Clinical Global Impression (CGI). To estimate treatment effects on social functioning in SAD we employed the Social Adaptation Self Evaluation Scale (SASS), the Sheehan Disability Scale (SDS), and assessments of days lost due to illness and days with reduction in productivity. RESULTS:Duloxetine led to a significant improvement (p<0.001) of SIGH-SAD, CGI severity, SASS, and SDS scores. Days lost due to illness and days with reduction in productivity were significantly diminished during treatment (p<0.001). Treatment with duloxetine over 8 weeks yielded a response rate (SIGH-SAD<50% of baseline value) of 80.8% and a remission rate (SIGH-SAD<8) of 76.9% in the intention to treat sample. The drop-out rate due to side effects was 15.4%. CONCLUSIONS: Our preliminary results indicate that duloxetine might be effective and able to ameliorate the negative social consequences of SAD.
Authors: Barbara Nussbaumer-Streit; Kylie Thaler; Andrea Chapman; Thomas Probst; Dietmar Winkler; Andreas Sönnichsen; Bradley N Gaynes; Gerald Gartlehner Journal: Cochrane Database Syst Rev Date: 2021-03-04
Authors: Maria Rosaria Anna Muscatello; Rocco A Zoccali; Gianluca Pandolfo; Paolo Mangano; Simona Lorusso; Clemente Cedro; Fortunato Battaglia; Edoardo Spina; Antonio Bruno Journal: Front Psychiatry Date: 2019-10-25 Impact factor: 4.157
Authors: Arshad Hussain; Majid Shafi Shah; Fazl E Roub; Mansoor Ahmad Dar; Zaid Ahmad Wani; Mohd Muzzaffar Jan; Rayees Ahmad Wani; Tariq Ahmad Bhat Journal: Indian J Psychol Med Date: 2015 Jul-Sep