| Literature DB >> 18484154 |
Abbas Delazar1, Araz Sabzevari, Mahdi Mojarrab, Hossein Nazemiyeh, Solmaz Esnaashari, Lutfun Nahar, Seied Mehdi Razavi, Satyajit Dey Sarker.
Abstract
Seven free-radical-scavenging phenolic compounds including five flavonoids, rutin (1), chrysoeriol 7-O-rutinoside (2), kaempferol 3-O-glucoside (3), chrysoeriol 7-O-glucoside (4) and naringenin (5), and two phenylethanoid glycosides, forsythoside B (6) and acteoside (7) were isolated from the methanol extract of the aerial parts of the Iranian medicinal plant Phlomis caucasica by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated by spectroscopic means. The free-radical-scavenging properties of 1-7 were assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay. Among these compounds, forsythoside B (6) and acteoside (7) were found to be the most potent antioxidants with the RC(50) values of 4.97 and 4.27 microg/ml, respectively.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18484154 DOI： 10.1007/s11418-008-0255-y
Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343