| Literature DB >> 1848377 |
M B Gardner1, C A Kozak, S J O'Brien.
Abstract
A small colony of feral mice from California continues to flourish in spite of a virulent epizootic of pathological retrovirus. Epidemiological and genetic studies revealed that the viral infection is strongly balanced by the polymorphic resistance locus, Fv-4, a transcriptionally active but truncated provirus that originated in the East Asian ancestors of the Californian mice. The natural history of these populations represents a graphic example of genomic adaptation in free-ranging populations to regulate and delimit infectious disease.Entities:
Mesh：
Substances：
Year: 1991 PMID： 1848377 DOI： 10.1016/0168-9525(91)90017-k
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639