Literature DB >> 18483197

Prevalence of tibiofemoral osteoarthritis 15 years after nonoperative treatment of anterior cruciate ligament injury: a prospective cohort study.

Paul Neuman1, Martin Englund, Ioannis Kostogiannis, Thomas Fridén, Harald Roos, Leif E Dahlberg.   

Abstract

BACKGROUND: The occurrence of osteoarthritis (OA), associated meniscal injuries, meniscectomy, and patient-related measures for patients treated nonoperatively after anterior cruciate ligament (ACL) injuries have not been well described in the literature in terms of natural history. HYPOTHESIS: Patients with ACL injury can achieve a low occurrence of tibiofemoral OA and good knee function when treated without ACL reconstruction. STUDY
DESIGN: Cohort study (prognosis); Level of evidence, 2.
METHODS: One hundred consecutive patients with an acute, complete ACL injury were observed for 15 years. All patients were primarily treated with activity modification and without ACL reconstruction. To achieve improved functional stability, supervised physical therapy was initiated early after injury. The patients were examined using anteroposterior weightbearing radiography. The Knee injury and Osteoarthritis Outcome Score (KOOS) was used to quantify knee-related symptoms and knee function.
RESULTS: Seventy-nine patients consented to radiographic examination and 93 completed the KOOS questionnaire. Thirteen patients (16%), all of whom were among the 35 patients whose knees were meniscectomized, developed radiographic tibiofemoral OA. In contrast, none of the remaining nonmeniscectomized and radiographed knees developed OA (n = 44) (P < .0001). Sixty-three patients (68%) had an asymptomatic knee. Twenty-two patients (23%) had undergone ACL reconstruction with a mean time of 4 years after injury.
CONCLUSION: The study had a favorable long-term outcome regarding incidence of radiographic knee OA, knee function and symptoms, and need for ACL reconstruction. Although risk factors for posttraumatic OA are multifactorial, the primary risk factor that stood out in this study was if a meniscectomy had been performed. Early activity modification and neuromuscular knee rehabilitation might also have been related to the low prevalence of radiographic knee OA. In patients with ACL injury willing to moderate activity level to avoid reinjury, initial treatment without ACL reconstruction should be considered.

Entities:  

Mesh:

Year:  2008        PMID: 18483197     DOI: 10.1177/0363546508316770

Source DB:  PubMed          Journal:  Am J Sports Med        ISSN: 0363-5465            Impact factor:   6.202


  102 in total

Review 1.  Muscle strength and hop performance criteria prior to return to sports after ACL reconstruction.

Authors:  Roland Thomeé; Yonatan Kaplan; Joanna Kvist; Grethe Myklebust; May Arna Risberg; Daniel Theisen; Elias Tsepis; Suzanne Werner; Barbara Wondrasch; Erik Witvrouw
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2011-09-20       Impact factor: 4.342

2.  Peripheral blood mononuclear cells enhance the anabolic effects of platelet-rich plasma on anterior cruciate ligament fibroblasts.

Authors:  Ryu Yoshida; Martha M Murray
Journal:  J Orthop Res       Date:  2012-07-05       Impact factor: 3.494

3.  Loading of the medial meniscus in the ACL deficient knee: A multibody computational study.

Authors:  Trent M Guess; Swithin Razu
Journal:  Med Eng Phys       Date:  2017-01-11       Impact factor: 2.242

4.  [Knee and ankle injuries from playing football].

Authors:  J Kramer; G Scheurecker
Journal:  Radiologe       Date:  2010-05       Impact factor: 0.635

5.  Osteoarthritis: Replacing the meniscus to prevent knee OA--fact or fiction?

Authors:  Martin Englund
Journal:  Nat Rev Rheumatol       Date:  2015-06-23       Impact factor: 20.543

6.  CORR Insights®: Variations in Knee Kinematics After ACL Injury and After Reconstruction Are Correlated With Bone Shape Differences.

Authors:  Robert Henry Brophy
Journal:  Clin Orthop Relat Res       Date:  2017-06-06       Impact factor: 4.176

Review 7.  Tibiofemoral Osteoarthritis After Surgical or Nonsurgical Treatment of Anterior Cruciate Ligament Rupture: A Systematic Review.

Authors:  Kyle P Harris; Jeffrey B Driban; Michael R Sitler; Nicole M Cattano; Easwaran Balasubramanian; Jennifer M Hootman
Journal:  J Athl Train       Date:  2015-06-26       Impact factor: 2.860

8.  Molecular influence of anterior cruciate ligament tear remnants on chondrocytes: a biologic connection between injury and osteoarthritis.

Authors:  N Chinzei; R H Brophy; X Duan; L Cai; R M Nunley; L J Sandell; M F Rai
Journal:  Osteoarthritis Cartilage       Date:  2018-01-31       Impact factor: 6.576

9.  Indentation properties and glycosaminoglycan content of human menisci in the deep zone.

Authors:  John T Moyer; Ryan Priest; Troy Bouman; Adam C Abraham; Tammy L Haut Donahue
Journal:  Acta Biomater       Date:  2013-01-12       Impact factor: 8.947

Review 10.  New developments in osteoarthritis. Prevention of injury-related knee osteoarthritis: opportunities for the primary and secondary prevention of knee osteoarthritis.

Authors:  Charles R Ratzlaff; Matthew H Liang
Journal:  Arthritis Res Ther       Date:  2010-08-31       Impact factor: 5.156

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