OBJECTIVE: The neural correlates of inhibitory deficits for emotional semantic material in persons with major depressive disorder (MDD) were investigated. METHODS: Individuals (n=15) with a diagnosis of MDD or MDD in partial remission, and healthy controls (n=14) underwent recording of event-related brain potentials (ERPs) while performing a computerized emotional Stroop task. RESULTS: There were no group performance differences on the emotional Stroop task. However, the analysis of ERP waveforms revealed a larger negative wave peaking at about 170ms over the left than the right hemisphere only in controls; a negative displacement (N450) at parietal sites for positive and negative words only for persons with MDD; in both groups, processing negative and positive words was associated with a positive displacement that peaked at about 450ms and was larger over the left lateral frontal region; and, the N450 modulation correlated with negative automatic thinking and depressive symptoms. CONCLUSIONS: The electrophysiological data reveal early changes in neural activity associated with word processing as well as valence-related changes in the N450 component at parietal sites in MDD. SIGNIFICANCE: This valence-related increase in N450 amplitude at parietal sites may reflect an automatic capture of attention by words with emotional valence.
OBJECTIVE: The neural correlates of inhibitory deficits for emotional semantic material in persons with major depressive disorder (MDD) were investigated. METHODS: Individuals (n=15) with a diagnosis of MDD or MDD in partial remission, and healthy controls (n=14) underwent recording of event-related brain potentials (ERPs) while performing a computerized emotional Stroop task. RESULTS: There were no group performance differences on the emotional Stroop task. However, the analysis of ERP waveforms revealed a larger negative wave peaking at about 170ms over the left than the right hemisphere only in controls; a negative displacement (N450) at parietal sites for positive and negative words only for persons with MDD; in both groups, processing negative and positive words was associated with a positive displacement that peaked at about 450ms and was larger over the left lateral frontal region; and, the N450 modulation correlated with negative automatic thinking and depressive symptoms. CONCLUSIONS: The electrophysiological data reveal early changes in neural activity associated with word processing as well as valence-related changes in the N450 component at parietal sites in MDD. SIGNIFICANCE: This valence-related increase in N450 amplitude at parietal sites may reflect an automatic capture of attention by words with emotional valence.
Authors: Joscelyn E Fisher; Sarah M Sass; Wendy Heller; Rebecca Levin Silton; J Christopher Edgar; Jennifer L Stewart; Gregory A Miller Journal: Emotion Date: 2010-08
Authors: Thomas Beblo; Christoph Mensebach; Katja Wingenfeld; Nina Rullkoetter; Nicole Schlosser; Martin Driessen Journal: Prim Care Companion CNS Disord Date: 2011
Authors: Brandon L Alderman; Ryan L Olson; Marsha E Bates; Edward A Selby; Jennifer F Buckman; Christopher J Brush; Emily A Panza; Amy Kranzler; David Eddie; Tracey J Shors Journal: Front Hum Neurosci Date: 2015-05-12 Impact factor: 3.473