| Literature DB >> 18482795 |
Elke Burgermeister1, Mordechai Liscovitch, Christoph Röcken, Roland M Schmid, Matthias P A Ebert.
Abstract
Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately gained recognition as a stage- and tissue-specific tumor modulator in vivo. Patient studies and rodent models corroborated its janus-faced role as a tumor suppressor in non-neoplastic tissue, its down-regulation (loss of function) upon transformation and its re-expression (regain of function) in advanced-stage metastatic and multidrug resistant tumors. This review is focussed on the role of caveolin-1 in metastasis and angiogenesis and its clinical implications as a prognostic marker in cancer progression.Entities:
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Year: 2008 PMID： 18482795 DOI： 10.1016/j.canlet.2008.03.055
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679