| Literature DB >> 1848277 |
P Marin1, J C Delumeau, O Durieu-Trautmann, D Le Nguyen, J Prémont, A D Strosberg, P O Couraud.
Abstract
High-affinity specific receptors of endothelin (ET-1) were identified on primary cultures of mouse embryo striatal astrocytes by binding experiments performed with 125I-ET-1. Stimulation of production of inositol phosphates, a biphasic increase of the intracellular calcium concentration, and inhibition of cyclic AMP accumulation were observed in the same cells under ET-1 stimulation. Pretreatment of these cells with Bordetella pertussis toxin affected these effects to different extends, an observation suggesting that they are mediated by multiple transduction pathways, possibly involving several guanine nucleotide-binding proteins.Entities:
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Year: 1991 PMID： 1848277 DOI： 10.1111/j.1471-4159.1991.tb11421.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372