OBJECTIVES: To examine the effects of dehydroepiandrosterone (DHEA) supplementation on cognitive function and quality of life in healthy older adults. DESIGN: Double-blind, randomized, controlled clinical trial. SETTING: Clinical research facility. PARTICIPANTS: One hundred ten men and 115 women aged 55 to 85 (mean +/- standard deviation 68 +/- 8). INTERVENTION: Fifty milligrams daily oral DHEA versus placebo for 1 year. MEASUREMENTS: Six cognitive function tests at baseline and 12 months, the Beck Depression Inventory (BDI), the Medical Outcomes Study 36-item Short Form Survey (SF-36), the Life Satisfaction Index-Z, the Satisfaction with Life Scale, the Female Sexual Function Index (in women), and the 15-item International Index of Erectile Function (in men) at baseline and 3, 6, and 12 months. RESULTS: There were no differences between the DHEA and placebo groups in change over time in cognitive function (P>.10). Over time, BDI scores decreased for men (P=.006) and women (P=.02), and Satisfaction with Life Scale scores increased for women (P=.004), but there were no differences between the DHEA and placebo groups over time on these measures or the SF-36, Life Satisfaction Index-Z scale, or sexual function scales (P>.10). CONCLUSION:DHEA supplementation has no benefit on cognitive performance or well-being in healthy older adults, and it should not be recommended for that purpose in the general population.
RCT Entities:
OBJECTIVES: To examine the effects of dehydroepiandrosterone (DHEA) supplementation on cognitive function and quality of life in healthy older adults. DESIGN: Double-blind, randomized, controlled clinical trial. SETTING: Clinical research facility. PARTICIPANTS: One hundred ten men and 115 women aged 55 to 85 (mean +/- standard deviation 68 +/- 8). INTERVENTION: Fifty milligrams daily oral DHEA versus placebo for 1 year. MEASUREMENTS: Six cognitive function tests at baseline and 12 months, the Beck Depression Inventory (BDI), the Medical Outcomes Study 36-item Short Form Survey (SF-36), the Life Satisfaction Index-Z, the Satisfaction with Life Scale, the Female Sexual Function Index (in women), and the 15-item International Index of Erectile Function (in men) at baseline and 3, 6, and 12 months. RESULTS: There were no differences between the DHEA and placebo groups in change over time in cognitive function (P>.10). Over time, BDI scores decreased for men (P=.006) and women (P=.02), and Satisfaction with Life Scale scores increased for women (P=.004), but there were no differences between the DHEA and placebo groups over time on these measures or the SF-36, Life Satisfaction Index-Z scale, or sexual function scales (P>.10). CONCLUSION:DHEA supplementation has no benefit on cognitive performance or well-being in healthy older adults, and it should not be recommended for that purpose in the general population.
Authors: T Sunderland; C R Merril; M G Harrington; B A Lawlor; S E Molchan; R Martinez; D L Murphy Journal: Lancet Date: 1989-09-02 Impact factor: 79.321
Authors: L F Berkman; T E Seeman; M Albert; D Blazer; R Kahn; R Mohs; C Finch; E Schneider; C Cotman; G McClearn Journal: J Clin Epidemiol Date: 1993-10 Impact factor: 6.437
Authors: Sybil Crawford; Nanette Santoro; Gail A Laughlin; Mary Fran Sowers; Daniel McConnell; Kim Sutton-Tyrrell; Gerson Weiss; Marike Vuga; John Randolph; Bill Lasley Journal: J Clin Endocrinol Metab Date: 2009-05-26 Impact factor: 5.958