Literature DB >> 18481993

Nonsense-mediated mRNA decay.

Jikai Wen1, Saverio Brogna.   

Abstract

Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the current understanding in view of recent developments.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18481993     DOI： 10.1042/BST0360514

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  27 in total

1.  cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish.

Authors:  Jolijn W Groeneweg; Yvonne A R White; David Kokel; Randall T Peterson; Lawrence R Zukerberg; Inna Berin; Bo R Rueda; Antony W Wood
Journal:  Mol Reprod Dev       Date:  2010-12-23       Impact factor: 2.609

2.  NPAS3 demonstrates features of a tumor suppressive role in driving the progression of Astrocytomas.

Authors:  Frederico Moreira; Tim-Rasmus Kiehl; Kelvin So; Norbert F Ajeawung; Carmelita Honculada; Peter Gould; Russell O Pieper; Deepak Kamnasaran
Journal:  Am J Pathol       Date:  2011-05-19       Impact factor: 4.307

3.  A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function.

Authors:  Feng Gao; Hansel E Ihn; Marisa W Medina; Ronald M Krauss
Journal:  Hum Mol Genet       Date:  2013-01-07       Impact factor: 6.150

4.  Identification of a novel frameshift mutation in PITX2 gene in a Chinese family with Axenfeld-Rieger syndrome.

Authors:  Hou-fa Yin; Xiao-yun Fang; Chong-fei Jin; Jin-fu Yin; Jin-yu Li; Su-juan Zhao; Qi Miao; Feng-wei Song
Journal:  J Zhejiang Univ Sci B       Date:  2014-01       Impact factor: 3.066

5.  Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.

Authors:  Michael Reuter; Philipp Berninger; Shinichiro Chuma; Hardik Shah; Mihoko Hosokawa; Charlotta Funaya; Claude Antony; Ravi Sachidanandam; Ramesh S Pillai
Journal:  Nature       Date:  2011-11-27       Impact factor: 49.962

6.  The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements.

Authors:  Serena De Fazio; Nenad Bartonicek; Monica Di Giacomo; Cei Abreu-Goodger; Aditya Sankar; Charlotta Funaya; Claude Antony; Pedro N Moreira; Anton J Enright; Dónal O'Carroll
Journal:  Nature       Date:  2011-10-23       Impact factor: 49.962

7.  Mutation discovered in a feline model of human congenital retinal blinding disease.

Authors:  Marilyn Menotti-Raymond; Koren Holland Deckman; Victor David; Jaimie Myrkalo; Stephen J O'Brien; Kristina Narfström
Journal:  Invest Ophthalmol Vis Sci       Date:  2010-01-06       Impact factor: 4.799

8.  APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA.

Authors:  Rebecca A Russell; Michael D Moore; Wei-Shau Hu; Vinay K Pathak
Journal:  Retrovirology       Date:  2009-02-13       Impact factor: 4.602

Review 9.  A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.

Authors:  King Leung Fung; Michael M Gottesman
Journal:  Biochim Biophys Acta       Date:  2009-03-11

10.  Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay.

Authors:  Zhenguo Zhang; Dedong Xin; Ping Wang; Li Zhou; Landian Hu; Xiangyin Kong; Laurence D Hurst
Journal:  BMC Biol       Date:  2009-05-14       Impact factor: 7.431
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.