Literature DB >> 18481980

Targeting IRFs by ubiquitination: regulating antiviral responses.

Rowan Higgs1, Caroline A Jefferies.   

Abstract

The IRF [IFN (interferon) regulatory factor] family of transcription factors control many cellular processes, including induction of key antiviral cytokines, type I IFNs, following viral infection. Recent studies have revealed several endogenous and viral proteins involved in ubiquitin-mediated regulation of IRF activity and thus having an impact on type I IFN signalling. Through the ubiquitin pathway, these proteins can manipulate the antiviral response either by initiating proteasomal degradation of the IRFs or, in contrast, by promoting activation of the IRFs.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18481980     DOI： 10.1042/BST0360453

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  11 in total

Review 1.  IRF7: activation, regulation, modification and function.

Authors:  S Ning; J S Pagano; G N Barber
Journal:  Genes Immun       Date:  2011-04-14       Impact factor: 2.676

2.  Cellular FLIP long isoform (cFLIPL)-IKKα interactions inhibit IRF7 activation, representing a new cellular strategy to inhibit IFNα expression.

Authors:  Lauren T Gates-Tanzer; Joanna L Shisler
Journal:  J Biol Chem       Date:  2017-12-08       Impact factor: 5.157

3.  Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.

Authors:  Rowan Higgs; Elisa Lazzari; Claire Wynne; Joan Ní Gabhann; Alexander Espinosa; Marie Wahren-Herlenius; Caroline A Jefferies
Journal:  PLoS One       Date:  2010-07-26       Impact factor: 3.240

Review 4.  Structural insights into interferon regulatory factor activation.

Authors:  Weijun Chen; William E Royer
Journal:  Cell Signal       Date:  2009-12-30       Impact factor: 4.315

5.  PLP2 of mouse hepatitis virus A59 (MHV-A59) targets TBK1 to negatively regulate cellular type I interferon signaling pathway.

Authors:  Gang Wang; Gang Chen; Dahai Zheng; Genhong Cheng; Hong Tang
Journal:  PLoS One       Date:  2011-02-18       Impact factor: 3.240

6.  Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression.

Authors:  Pierre Génin; Rongtuan Lin; John Hiscott; Ahmet Civas
Journal:  PLoS One       Date:  2012-06-07       Impact factor: 3.240

7.  Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity.

Authors:  Kevin B Stacey; Eamon Breen; Caroline A Jefferies
Journal:  PLoS One       Date:  2012-03-30       Impact factor: 3.240

Review 8.  Regulating IRFs in IFN Driven Disease.

Authors:  Caroline A Jefferies
Journal:  Front Immunol       Date:  2019-03-29       Impact factor: 7.561

9.  Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3.

Authors:  Hui Hui Wong; To Sing Fung; Shouguo Fang; Mei Huang; My Tra Le; Ding Xiang Liu
Journal:  Virology       Date:  2017-12-30       Impact factor: 3.616

Review 10.  Ubiquitination modification: critical regulation of IRF family stability and activity.

Authors:  Bao-Qin Liu; Jin Jin; Yi-Yuan Li
Journal:  Sci China Life Sci       Date:  2020-10-30       Impact factor: 6.038
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.