BACKGROUND: This study examined the association between maternal smoking and alcohol use (including binge drinking) during the periconceptional period (i.e., 2 months before through 2 months after conception) and the risk of orofacial clefts, NTDs, and conotruncal heart defects in offspring. METHODS: Data were drawn from a population-based case-control study of fetuses and live-born infants among a cohort of California births between July 1999 and June 2003. The 1,355 cases comprised of 701 orofacial clefts, 337 NTDs, and 323 conotruncal heart defects. Information on smoking and alcohol consumption was obtained via telephone interviews with mothers of 1,355 (80% of eligibles) cases and 700 (77% of eligibles) nonmalformed, live-born controls. RESULTS: Maternal smoking of five cigarettes or less per day was associated with reduced risks of NTDs (OR 0.7; 95% CI: 0.3, 1.4), whereas the risk associated with higher cigarette consumption was lower for conotruncal heart defects (OR 0.5; 95% CI: 0.2, 1.2). Maternal intake of alcohol less than 1 day per week was associated with a 1.6- to 2.1-fold higher risk of NTDs (95% CI: 0.9, 2.6), d-transposition of the great arteries (95% CI: 1.1, 3.2), and multiple cleft lip with or without cleft palate (CLP) (95% CI: 0.8, 4.5). Risks associated with more frequent alcohol intake were 2.1 for NTDs (95% CI: 1.1, 4.0) and 2.6 for multiple CLP (95% CI: 1.1, 6.1). CONCLUSIONS: This study observed that maternal alcohol intake increased the risk for d-transposition of the great arteries, NTDs, and multiple CLP in infants. By contrast, smoking was associated with a lower risk of NTDs and conotruncal heart defects. (c) 2008 Wiley-Liss, Inc.
BACKGROUND: This study examined the association between maternal smoking and alcohol use (including binge drinking) during the periconceptional period (i.e., 2 months before through 2 months after conception) and the risk of orofacial clefts, NTDs, and conotruncal heart defects in offspring. METHODS: Data were drawn from a population-based case-control study of fetuses and live-born infants among a cohort of California births between July 1999 and June 2003. The 1,355 cases comprised of 701 orofacial clefts, 337 NTDs, and 323 conotruncal heart defects. Information on smoking and alcohol consumption was obtained via telephone interviews with mothers of 1,355 (80% of eligibles) cases and 700 (77% of eligibles) nonmalformed, live-born controls. RESULTS: Maternal smoking of five cigarettes or less per day was associated with reduced risks of NTDs (OR 0.7; 95% CI: 0.3, 1.4), whereas the risk associated with higher cigarette consumption was lower for conotruncal heart defects (OR 0.5; 95% CI: 0.2, 1.2). Maternal intake of alcohol less than 1 day per week was associated with a 1.6- to 2.1-fold higher risk of NTDs (95% CI: 0.9, 2.6), d-transposition of the great arteries (95% CI: 1.1, 3.2), and multiple cleft lip with or without cleft palate (CLP) (95% CI: 0.8, 4.5). Risks associated with more frequent alcohol intake were 2.1 for NTDs (95% CI: 1.1, 4.0) and 2.6 for multiple CLP (95% CI: 1.1, 6.1). CONCLUSIONS: This study observed that maternal alcohol intake increased the risk for d-transposition of the great arteries, NTDs, and multiple CLP in infants. By contrast, smoking was associated with a lower risk of NTDs and conotruncal heart defects. (c) 2008 Wiley-Liss, Inc.
Authors: Edward P Riley; Sarah N Mattson; Ting-Kai Li; Sandra W Jacobson; Claire D Coles; P W Kodituwakku; Colleen M Adnams; Marit I Korkman Journal: Alcohol Clin Exp Res Date: 2003-02 Impact factor: 3.455
Authors: Sandra Richardson; Marilyn L Browne; Sonja A Rasmussen; Charlotte M Druschel; Lixian Sun; Ethylin Wang Jabs; Paul A Romitti Journal: Birth Defects Res A Clin Mol Teratol Date: 2011-05-31
Authors: Lucina Suarez; Tunu Ramadhani; Marilyn Felkner; Mark A Canfield; Jean D Brender; Paul A Romitti; Lixian Sun Journal: Birth Defects Res A Clin Mol Teratol Date: 2010-11-15
Authors: Lindsy M Peterson; Shi Gu; Ganga Karunamuni; Michael W Jenkins; Michiko Watanabe; Andrew M Rollins Journal: Biomed Opt Express Date: 2017-02-24 Impact factor: 3.732
Authors: Jennifer A Makelarski; Paul A Romitti; Lixian Sun; Trudy L Burns; Charlotte M Druschel; Lucina Suarez; Andrew F Olshan; Anna Maria Siega-Riz; Richard S Olney Journal: Birth Defects Res A Clin Mol Teratol Date: 2013-03-04
Authors: Rebecca J Schmidt; Paul A Romitti; Trudy L Burns; Marilyn L Browne; Charlotte M Druschel; Richard S Olney Journal: Birth Defects Res A Clin Mol Teratol Date: 2009-11