Literature DB >> 18481454

The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rgamma(null) mice.

F Ishikawa1, Y Saito, S Yoshida, M Harada, L D Shultz.   

Abstract

Biomedical research including immunology and stem cell biology has developed greatly because of the evolving technology of gene modification and conventional transplantation methods using the most common experimental laboratory animal, the mouse. To translate promising research findings based on mouse research into clinical medicine, however, we need to clarify whether similar events take place in humans. In the study of hematology and immunology, humanized mice provide a unique and efficient experimental system to evaluate differentiation, function, and interaction of human blood cells or immune components. Here we review the latest experimental findings in the fields of immunology, stem cell biology, and regenerative medicine using humanized mice.

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Year:  2008        PMID： 18481454     DOI： 10.1007/978-3-540-75647-7_5

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  6 in total

1.  Distinct but phenotypically heterogeneous human cell populations produce rapid recovery of platelets and neutrophils after transplantation.

Authors:  Alice M S Cheung; Donna Leung; Shabnam Rostamirad; Kiran Dhillon; Paul H Miller; Radina Droumeva; Ryan R Brinkman; Donna Hogge; Denis Claude Roy; Connie J Eaves
Journal:  Blood       Date:  2012-02-28       Impact factor: 22.113

2.  Establishment of a xenograft model of human myelodysplastic syndromes.

Authors:  Yukari Muguruma; Hiromichi Matsushita; Takashi Yahata; Shizu Yumino; Yumiko Tanaka; Hayato Miyachi; Yoshiaki Ogawa; Hiroshi Kawada; Mamoru Ito; Kiyoshi Ando
Journal:  Haematologica       Date:  2010-12-29       Impact factor: 9.941

3.  Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity.

Authors:  Sung P Ha; Nicholas D Klemen; Garrett H Kinnebrew; Andrew G Brandmaier; Jon Marsh; Giao Hangoc; Douglas C Palmer; Nicholas P Restifo; Kenneth Cornetta; Hal E Broxmeyer; Christopher E Touloukian
Journal:  J Clin Invest       Date:  2010-11-15       Impact factor: 14.808

4.  A humanized mouse model to study asthmatic airway inflammation via the human IL-33/IL-13 axis.

Authors:  Ryoji Ito; Shuichiro Maruoka; Kaori Soda; Ikumi Katano; Kenji Kawai; Mika Yagoto; Asami Hanazawa; Takeshi Takahashi; Tomoyuki Ogura; Motohito Goto; Riichi Takahashi; Shota Toyoshima; Yoshimichi Okayama; Kenji Izuhara; Yasuhiro Gon; Shu Hashimoto; Mamoru Ito; Satoshi Nunomura
Journal:  JCI Insight       Date:  2018-11-02

5.  Recovery and Biodistribution of Ex Vivo Expanded Human Erythroblasts Injected into NOD/SCID/IL2Rγ mice.

Authors:  Barbara Ghinassi; Leda Ferro; Francesca Masiello; Valentina Tirelli; Massimo Sanchez; Giovanni Migliaccio; Carolyn Whitsett; Stefan Kachala; Isabelle Riviere; Michel Sadelain; Anna Rita Migliaccio
Journal:  Stem Cells Int       Date:  2011-08-16       Impact factor: 5.443

Review 6.  Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?

Authors:  Axel Schulenburg; Katharina Blatt; Sabine Cerny-Reiterer; Irina Sadovnik; Harald Herrmann; Brigitte Marian; Thomas W Grunt; Christoph C Zielinski; Peter Valent
Journal:  J Hematol Oncol       Date:  2015-02-25       Impact factor: 17.388
  6 in total

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