BACKGROUND: Although some previous studies have reported that genetic and immunological factors play important roles in the pathogenesis of Kawasaki disease (KD), the etiological factors of this enigmatical pediatric disease are still poorly understood. PURPOSE: This study aims to investigate whether polymorphisms of the CD40 ligand (CD40L) gene are associated with KD and the development of coronary artery lesions (CAL) in the Taiwanese children. MATERIALS AND METHODS: The CD40L -3459 A/G and IVS4+121 A/G single nucleotide polymorphisms (SNPs) were genotyped in 167 children with KD and 1,010 ethnically matched healthy controls by TaqMan assay. RESULTS: None of the CD40L polymorphisms was associated with susceptibility or CAL development of KD, and this finding was supported by the haplotype analysis. CONCLUSION: In summary, these results provide little support for specific CD40L SNPs in the susceptibility or CAL development of KD in Taiwanese children. However, it will be necessary to validate or replicate this association in other independent large-size ethnic groups.
BACKGROUND: Although some previous studies have reported that genetic and immunological factors play important roles in the pathogenesis of Kawasaki disease (KD), the etiological factors of this enigmatical pediatric disease are still poorly understood. PURPOSE: This study aims to investigate whether polymorphisms of the CD40 ligand (CD40L) gene are associated with KD and the development of coronary artery lesions (CAL) in the Taiwanese children. MATERIALS AND METHODS: The CD40L-3459 A/G and IVS4+121 A/G single nucleotide polymorphisms (SNPs) were genotyped in 167 children with KD and 1,010 ethnically matched healthy controls by TaqMan assay. RESULTS: None of the CD40L polymorphisms was associated with susceptibility or CAL development of KD, and this finding was supported by the haplotype analysis. CONCLUSION: In summary, these results provide little support for specific CD40L SNPs in the susceptibility or CAL development of KD in Taiwanese children. However, it will be necessary to validate or replicate this association in other independent large-size ethnic groups.
Authors: A S Dajani; K A Taubert; M A Gerber; S T Shulman; P Ferrieri; M Freed; M Takahashi; F Z Bierman; A W Karchmer; W Wilson Journal: Circulation Date: 1993-05 Impact factor: 29.690
Authors: K Kato; E Santana-Sahagún; L Z Rassenti; M H Weisman; N Tamura; S Kobayashi; H Hashimoto; T J Kipps Journal: J Clin Invest Date: 1999-10 Impact factor: 14.808
Authors: Mi Hyun Kim; Yon Jung Bae; Hyun Keun Lee; Yeong Ro Lee; Dong Hoon Lee; Kiho Bae; Sang Baek Koh; Mee Kyung Namgoong; Byung Ho Cha; Hae Yong Lee Journal: Korean Circ J Date: 2013-01-31 Impact factor: 3.243