Literature DB >> 18479678

Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis.

Arthur T Crossman1, Michael D Urbaniak, Michael A J Ferguson.   

Abstract

1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate) was prepared to probe the reaction mechanism of the putative zinc-dependent metalloenzyme 2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1-->6)-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis.

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Year:  2008        PMID： 18479678     DOI： 10.1016/j.carres.2008.03.028

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN： 0008-6215            Impact factor:   2.104


  2 in total

1.  Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei.

Authors:  Nuha Z Abdelwahab; Michael D Urbaniak; Michael A J Ferguson; Arthur T Crossman
Journal:  Carbohydr Res       Date:  2011-02-24       Impact factor: 2.104

2.  Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness.

Authors:  Nuha Z Abdelwahab; Arthur T Crossman; Lauren Sullivan; Michael A J Ferguson; Michael D Urbaniak
Journal:  Chem Biol Drug Des       Date:  2012-03       Impact factor: 2.817
  2 in total

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