OBJECTIVE: Prefrontal cortical dysfunction is considered to be critical in the pathogenesis of schizophrenia. However, structural magnetic resonance imaging (MRI) studies on the PFC have yielded inconsistent results because of various confounding factors. METHOD: In this study we examined the volume and thickness abnormalities of the PFC in antipsychotic-naïve schizophrenia patients (n = 51) in comparison with age-, sex-, and handedness-matched (as a group) healthy comparison subjects (n = 47) using a newly described automated MRI parcellation analysis. RESULTS: Schizophrenia patients showed i) significant volume deficits in bilateral lateral orbitofrontal and left medial orbitofrontal cortices as well as bilateral pars triangularis; and ii) significant thickness deficit in bilateral medial orbitofrontal cortices. Negative syndrome score had a significant negative correlation with the thickness of the left medial orbitofrontal cortex. CONCLUSION: The study findings emphasize that prefrontal deficit in schizophrenia is differential and involves primarily the regions essential for 'social cognition'.
OBJECTIVE: Prefrontal cortical dysfunction is considered to be critical in the pathogenesis of schizophrenia. However, structural magnetic resonance imaging (MRI) studies on the PFC have yielded inconsistent results because of various confounding factors. METHOD: In this study we examined the volume and thickness abnormalities of the PFC in antipsychotic-naïve schizophreniapatients (n = 51) in comparison with age-, sex-, and handedness-matched (as a group) healthy comparison subjects (n = 47) using a newly described automated MRI parcellation analysis. RESULTS:Schizophreniapatients showed i) significant volume deficits in bilateral lateral orbitofrontal and left medial orbitofrontal cortices as well as bilateral pars triangularis; and ii) significant thickness deficit in bilateral medial orbitofrontal cortices. Negative syndrome score had a significant negative correlation with the thickness of the left medial orbitofrontal cortex. CONCLUSION: The study findings emphasize that prefrontal deficit in schizophrenia is differential and involves primarily the regions essential for 'social cognition'.
Authors: Eric Plitman; Shinichiro Nakajima; Camilo de la Fuente-Sandoval; Philip Gerretsen; M Mallar Chakravarty; Jane Kobylianskii; Jun Ku Chung; Fernando Caravaggio; Yusuke Iwata; Gary Remington; Ariel Graff-Guerrero Journal: Eur Neuropsychopharmacol Date: 2014-08-01 Impact factor: 4.600
Authors: Carl Christoph Schultz; Igor Nenadic; Brien Riley; Vladimir I Vladimirov; Gerd Wagner; Kathrin Koch; Claudia Schachtzabel; Thomas W Mühleisen; Buket Basmanav; Markus M Nöthen; Thomas Deufel; Michael Kiehntopf; Marcella Rietschel; Jürgen R Reichenbach; Sven Cichon; Ralf G M Schlösser; Heinrich Sauer Journal: Schizophr Bull Date: 2013-09-27 Impact factor: 9.306
Authors: C Christoph Schultz; Paolo Fusar-Poli; Gerd Wagner; Kathrin Koch; Claudia Schachtzabel; Oliver Gruber; Heinrich Sauer; Ralf G M Schlösser Journal: Eur Arch Psychiatry Clin Neurosci Date: 2012-09-02 Impact factor: 5.270
Authors: Tyler A Lesh; Costin Tanase; Benjamin R Geib; Tara A Niendam; Jong H Yoon; Michael J Minzenberg; J Daniel Ragland; Marjorie Solomon; Cameron S Carter Journal: JAMA Psychiatry Date: 2015-03 Impact factor: 21.596
Authors: N R Sciolino; M Bortolato; S A Eisenstein; J Fu; F Oveisi; A G Hohmann; D Piomelli Journal: Neuroscience Date: 2010-04-13 Impact factor: 3.590
Authors: Hamid M Abdolmaleky; Adam C Gower; Chen-Khuan Wong; Jiayi W Cox; Xiaoling Zhang; Arunthathi Thiagalingam; Rahim Shafa; Vadivelu Sivaraman; Jin-Rong Zhou; Sam Thiagalingam Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2018-11-23 Impact factor: 3.568
Authors: Matthew S Panizzon; Christine Fennema-Notestine; Lisa T Eyler; Terry L Jernigan; Elizabeth Prom-Wormley; Michael Neale; Kristen Jacobson; Michael J Lyons; Michael D Grant; Carol E Franz; Hong Xian; Ming Tsuang; Bruce Fischl; Larry Seidman; Anders Dale; William S Kremen Journal: Cereb Cortex Date: 2009-03-18 Impact factor: 5.357
Authors: Tejas S Bhojraj; Alan N Francis; Rajaprabhakaran Rajarethinam; Shaun Eack; Shreedhar Kulkarni; Konasale M Prasad; Debra M Montrose; Diana Dworakowski; Vaibhav Diwadkar; Matcheri S Keshavan Journal: Schizophr Res Date: 2009-10-17 Impact factor: 4.939