OBJECTIVE: To determine whether results of histologic examination of hepatic biopsy samples could be used as an indicator of survival time in dogs that underwent surgical correction of a congenital portosystemic shunt (PSS). DESIGN: Retrospective case series. ANIMALS: 64 dogs that underwent exploratory laparotomy for an extrahepatic (n = 39) or intrahepatic (25) congenital PSS. PROCEDURES: All H&E-stained histologic slides of hepatic biopsy samples obtained at the time of surgery were reviewed by a single individual, and severity of histologic abnormalities (ie, arteriolar hyperplasia, biliary hyperplasia, fibrosis, cell swelling, lipidosis, lymphoplasmacytic cholangiohepatitis, suppurative cholangiohepatitis, lipid granulomas, and dilated sinusoids) was graded. A Cox proportional hazards regression model was used to determine whether each histologic feature was associated with survival time. RESULTS: Median follow-up time was 35.7 months, and median survival time was 50.6 months. Thirty-eight dogs were alive at the time of final follow-up; 15 had died of causes associated with the PSS, including 4 that died immediately after surgery; 3 had died of unrelated causes; and 8 were lost to follow-up. None of the histologic features examined were significantly associated with survival time. CONCLUSIONS AND CLINICAL RELEVANCE: Findings suggested that results of histologic examination of hepatic biopsy samples obtained at the time of surgery cannot be used to predict long-term outcome in dogs undergoing surgical correction of a PSS.
OBJECTIVE: To determine whether results of histologic examination of hepatic biopsy samples could be used as an indicator of survival time in dogs that underwent surgical correction of a congenital portosystemic shunt (PSS). DESIGN: Retrospective case series. ANIMALS: 64 dogs that underwent exploratory laparotomy for an extrahepatic (n = 39) or intrahepatic (25) congenital PSS. PROCEDURES: All H&E-stained histologic slides of hepatic biopsy samples obtained at the time of surgery were reviewed by a single individual, and severity of histologic abnormalities (ie, arteriolar hyperplasia, biliary hyperplasia, fibrosis, cell swelling, lipidosis, lymphoplasmacytic cholangiohepatitis, suppurative cholangiohepatitis, lipid granulomas, and dilated sinusoids) was graded. A Cox proportional hazards regression model was used to determine whether each histologic feature was associated with survival time. RESULTS: Median follow-up time was 35.7 months, and median survival time was 50.6 months. Thirty-eight dogs were alive at the time of final follow-up; 15 had died of causes associated with the PSS, including 4 that died immediately after surgery; 3 had died of unrelated causes; and 8 were lost to follow-up. None of the histologic features examined were significantly associated with survival time. CONCLUSIONS AND CLINICAL RELEVANCE: Findings suggested that results of histologic examination of hepatic biopsy samples obtained at the time of surgery cannot be used to predict long-term outcome in dogs undergoing surgical correction of a PSS.
Authors: Lindsay Van den Bossche; Vivien A C Schoonenberg; Iwan A Burgener; Louis C Penning; Ingrid M Schrall; Hedwig S Kruitwagen; Monique E van Wolferen; Guy C M Grinwis; Anne Kummeling; Jan Rothuizen; Jeroen F van Velzen; Nikolas Stathonikos; Martijn R Molenaar; Bernd J Helms; Jos F H M Brouwers; Bart Spee; Frank G van Steenbeek Journal: PLoS One Date: 2017-10-19 Impact factor: 3.240
Authors: Merle Toom; Jimmy H Saunders; Luc Duchateau; Goncalo Serrano; Hilde De Rooster; Nausikaa Devriendt; Emmelie Stock Journal: Front Vet Sci Date: 2022-09-26
Authors: Lindsay Van den Bossche; Frank G van Steenbeek; Maarten F Weber; Bart Spee; Louis C Penning; Freek J van Sluijs; Flin Zomerdijk; Marian J A Groot Koerkamp; Jan Rothuizen; Iwan A Burgener; Anne Kummeling Journal: J Vet Intern Med Date: 2018-05-17 Impact factor: 3.333