Literature DB >> 18478622

Computational design and discovery of conformationally flexible inhibitors of acetohydroxyacid synthase to overcome drug resistance associated with the W586L mutation.

Feng-Qin Ji1, Cong-Wei Niu, Chao-Nan Chen, Qiong Chen, Guang-Fu Yang, Zhen Xi, Chang-Guo Zhan.   

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Year:  2008        PMID: 18478622     DOI: 10.1002/cmdc.200800103

Source DB:  PubMed          Journal:  ChemMedChem        ISSN: 1860-7179            Impact factor:   3.466


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  5 in total

1.  Mechanism of isoproturon resistance in Phalaris minor: in silico design, synthesis and testing of some novel herbicides for regaining sensitivity.

Authors:  Durg Vijay Singh; Kuruba Adeppa; Krishna Misra
Journal:  J Mol Model       Date:  2011-07-15       Impact factor: 1.810

2.  Structural insights into the mechanism of inhibition of AHAS by herbicides.

Authors:  Thierry Lonhienne; Mario D Garcia; Gregory Pierens; Mehdi Mobli; Amanda Nouwens; Luke W Guddat
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-13       Impact factor: 11.205

3.  Computational simulations of structural role of the active-site W374C mutation of acetyl-coenzyme-A carboxylase: multi-drug resistance mechanism.

Authors:  Xiao-Lei Zhu; Wen-Chao Yang; Ning-Xi Yu; Sheng-Gang Yang; Guang-Fu Yang
Journal:  J Mol Model       Date:  2010-05-25       Impact factor: 1.810

4.  Structural basis of resistance to herbicides that target acetohydroxyacid synthase.

Authors:  Thierry Lonhienne; Yan Cheng; Mario D Garcia; Shu Hong Hu; Yu Shang Low; Gerhard Schenk; Craig M Williams; Luke W Guddat
Journal:  Nat Commun       Date:  2022-06-11       Impact factor: 17.694

5.  Subnanomolar inhibitor of cytochrome bc1 complex designed by optimizing interaction with conformationally flexible residues.

Authors:  Pei-Liang Zhao; Le Wang; Xiao-Lei Zhu; Xiaoqin Huang; Chang-Guo Zhan; Jia-Wei Wu; Guang-Fu Yang
Journal:  J Am Chem Soc       Date:  2010-01-13       Impact factor: 15.419

  5 in total

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