| Literature DB >> 18477510 |
Gerda Brunhofer1, Norbert Handler, Klaus Leisser, Christian R Studenik, Thomas Erker.
Abstract
The following study describes the synthesis of new benzanilide derivatives and their pharmacological investigation on smooth muscle preparations of guinea pigs. All compounds were synthesized in good yields and showed a spasmolytic activity without significant effect on vascular smooth muscles and heart muscle preparations. Moreover, further pharmacological investigations as well as in silico studies were performed to elucidate the mechanism of action. Compound 3 showed the most potent spasmolytic activity with an IC(50) of 3.25microM.Entities:
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Year: 2008 PMID： 18477510 DOI： 10.1016/j.bmc.2008.04.057
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641