Etsuko Ikeda1, Takashi Tsuji. 1. Faculty of Industrial Science and Technology Tokyo University of Science, Department of Biological Science and Technology, Noda, Chiba 278-8510, Japan.
Abstract
BACKGROUND: The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs that can replace organs lost or damaged due to disease, injury or aging. Dental regenerative medicine has made the most progress and is the most useful model for the consideration of strategies in future organ replacement therapies. OBJECTIVE: This review describes strategies that have been pursued to date and experiments currently being conducted to bioengineer teeth in anticipation of the production of fully functional organs. METHODS: To realize the practical application of 'bioengineered tooth' transplantation therapy, four major hurdles must be overcome. The present status of the hurdles to this therapy are described and discussed in this review. RESULTS/ CONCLUSION: The bioengineering techniques developed for tooth regeneration will in the future make substantial contributions to the ability to grow primordial organs in vitro and also to grow fully functioning organs, such as the liver, kidney and heart.
BACKGROUND: The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs that can replace organs lost or damaged due to disease, injury or aging. Dental regenerative medicine has made the most progress and is the most useful model for the consideration of strategies in future organ replacement therapies. OBJECTIVE: This review describes strategies that have been pursued to date and experiments currently being conducted to bioengineer teeth in anticipation of the production of fully functional organs. METHODS: To realize the practical application of 'bioengineered tooth' transplantation therapy, four major hurdles must be overcome. The present status of the hurdles to this therapy are described and discussed in this review. RESULTS/ CONCLUSION: The bioengineering techniques developed for tooth regeneration will in the future make substantial contributions to the ability to grow primordial organs in vitro and also to grow fully functioning organs, such as the liver, kidney and heart.
Authors: Federico Ferro; Renza Spelat; Giuseppe Falini; Annarita Gallelli; Federica D'Aurizio; Elisa Puppato; Maura Pandolfi; Antonio Paolo Beltrami; Daniela Cesselli; Carlo Alberto Beltrami; Francesco Saverio Ambesi-Impiombato; Francesco Curcio Journal: Am J Pathol Date: 2011-05 Impact factor: 4.307
Authors: Zeinab F Hosseini; Deirdre A Nelson; Nicholas Moskwa; Lauren M Sfakis; James Castracane; Melinda Larsen Journal: J Cell Sci Date: 2018-02-20 Impact factor: 5.285