Elena Ambrosino1, Jay A Berzofsky, Masaki Terabe. 1. National Cancer Institute, Center for Cancer Research, Molecular Immunogenetics and Vaccine Research Section, Vaccine Branch, NIH, Building 10/Room 6B12, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
Abstract
BACKGROUND: Tumor immunosurveillance is a part of the dynamic process of interaction between abnormal cells and the host immune system. Tumor immunosurveillance is actively and continuously regulated in both positive and negative ways. Natural killer T (NKT) cells are cells that have been shown to play a role in both positive and negative regulation of tumor immunosurveillance. Recent studies suggest that NKT cells are a heterogeneous cell population with multiple subsets with distinct functions. OBJECTIVE: This review discusses the functions of those NKT cell subsets in regulating tumor immunity and potential interactions or counter-regulation among the NKT cell subsets. METHOD: Selected literature is reviewed. CONCLUSION: Manipulation of the balance among those subsets may provide new modes of intervention for tumor immunotherapy.
BACKGROUND:Tumor immunosurveillance is a part of the dynamic process of interaction between abnormal cells and the host immune system. Tumor immunosurveillance is actively and continuously regulated in both positive and negative ways. Natural killer T (NKT) cells are cells that have been shown to play a role in both positive and negative regulation of tumor immunosurveillance. Recent studies suggest that NKT cells are a heterogeneous cell population with multiple subsets with distinct functions. OBJECTIVE: This review discusses the functions of those NKT cell subsets in regulating tumor immunity and potential interactions or counter-regulation among the NKT cell subsets. METHOD: Selected literature is reviewed. CONCLUSION: Manipulation of the balance among those subsets may provide new modes of intervention for tumor immunotherapy.
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