| Literature DB >> 18476713 |
Jing Wang1, Fang Yu, Xiaojing Zhang, Dawei Ma.
Abstract
The diarylprolinol ether/HOAc-catalyzed cascade Michael addition and cyclization of aldehydes and alpha-keto-alpha,beta-unsaturated esters proceeds smoothly in water to afford cyclic hemiacetals, which are oxidized to furnish highly functionalized 3,4,5,6-tetrasubstituted dihydropyrones with excellent enantioselectivities.Entities:
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Year: 2008 PMID： 18476713 DOI： 10.1021/ol800835m
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005