Literature DB >> 18476706

A direct stereoselective approach to trans-2,3-disubstituted piperidines: application in the synthesis of 2-Epi-CP-99,994 and (+)-epilupinine.

M'hamed Ahari1, Amandine Perez, Christine Menant, Jean-Luc Vasse, Jan Szymoniak.   

Abstract

A simple synthesis of enantiomerically pure piperidine esters is described, offering a straightforward access to the trans-2,3-disubstituted piperidine skeleton which is present in a broad range of biologically active compounds.

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Year:  2008        PMID： 18476706     DOI： 10.1021/ol800722a

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Iminium Ion Cascade Reactions: Stereoselective Synthesis of Quinolizidines and Indolizidines.

Authors:  Shawn M Amorde; Ivan T Jewett; Stephen F Martin
Journal:  Tetrahedron       Date:  2009-04-19       Impact factor: 2.457

2.  Synthesis of (+)-CP-99,994 via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H Diamination of terminal olefin.

Authors:  Renzhong Fu; Baoguo Zhao; Yian Shi
Journal:  J Org Chem       Date:  2009-10-02       Impact factor: 4.354

3.  Asymmetric synthesis of (2S,3R)-(-)-epi-CP-99,994 using sulfinimine-derived anti-2,3-diamino esters.

Authors:  Franklin A Davis; Yanfeng Zhang
Journal:  Tetrahedron Lett       Date:  2009-11-16       Impact factor: 2.415
  3 in total

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