Literature DB >> 18475748

Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels.

A L Pukhalsky1, M S Bliacher, A V Danilina, E A Kalashnikova, T K Lopatina, I M Fedorova.   

Abstract

The effect of vaccination with diphtheria toxoid (AD-M) on TNF and IL-6 production has been studied in humans. In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppressed but IL-6 production was stimulated. On the other hand, serum levels of TNF were markedly increased over a period of 3 weeks. It was also demonstrated that the postvaccinal cytokine production disturbances may be corrected by pretreatment with a new synthetic hexapeptid (Imunofan((R))). It is possible that the imunofan treatment could prevent some postvaccinal complications.

Entities:  

Year:  1996        PMID： 18475748      PMCID： PMC2365819          DOI： 10.1155/S0962935196000592

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN： 0962-9351            Impact factor:   4.711


  7 in total

1.  Levels of interleukin 6 and tumor necrosis factor in serum from humans vaccinated with live, attenuated Francisella tularensis.

Authors:  T Krakauer
Journal:  Clin Diagn Lab Immunol       Date:  1995-07

2.  Differential expression of proinflammatory cytokines and their inhibitors during the course of meningococcal infections.

Authors:  M van Deuren; J van der Ven-Jongekrijg; P N Demacker; A K Bartelink; R van Dalen; R W Sauerwein; H Gallati; J L Vannice; J W van der Meer
Journal:  J Infect Dis       Date:  1994-01       Impact factor: 5.226

3.  Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.

Authors:  H Tilg; E Trehu; M B Atkins; C A Dinarello; J W Mier
Journal:  Blood       Date:  1994-01-01       Impact factor: 22.113

Review 4.  [Contribution of cytokines to inflammatory mechanisms].

Authors:  J M Cavaillon
Journal:  Pathol Biol (Paris)       Date:  1993-10

5.  Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease.

Authors:  K Fassbender; S Rossol; T Kammer; M Daffertshofer; S Wirth; M Dollman; M Hennerici
Journal:  J Neurol Sci       Date:  1994-04       Impact factor: 3.181

6.  Cytokine production in the murine response to brucella infection or immunization with antigenic extracts.

Authors:  Y Zhan; A Kelso; C Cheers
Journal:  Immunology       Date:  1993-11       Impact factor: 7.397

7.  Changes in cytokine production after measles virus vaccination: predominant production of IL-4 suggests induction of a Th2 response.

Authors:  B J Ward; D E Griffin
Journal:  Clin Immunol Immunopathol       Date:  1993-05
  7 in total
  2 in total

1.  Imunofan-RDKVYR Peptide-Stimulates Skin Cell Proliferation and Promotes Tissue Repair.

Authors:  Justyna Sawicka; Maria Dzierżyńska; Anna Wardowska; Milena Deptuła; Piotr Rogujski; Paweł Sosnowski; Natalia Filipowicz; Alina Mieczkowska; Piotr Sass; Anna Pawlik; Aleksandra Hać; Adriana Schumacher; Magdalena Gucwa; Natalia Karska; Jolanta Kamińska; Rafał Płatek; Jarosław Mazuryk; Jacek Zieliński; Karolina Kondej; Piotr Młynarz; Piotr Mucha; Piotr Skowron; Łukasz Janus; Anna Herman-Antosiewicz; Paweł Sachadyn; Artur Czupryn; Arkadiusz Piotrowski; Michał Pikuła; Sylwia Rodziewicz-Motowidło
Journal:  Molecules       Date:  2020-06-23       Impact factor: 4.411

2.  ChAdOx1 vaccination, blood coagulation, and inflammation: No effect on coagulation but increased interleukin-6.

Authors:  Loes H Willems; Magdolna Nagy; Hugo Ten Cate; Henri M H Spronk; Lotte M C Jacobs; Josephine Kranendonk; Maaike van Leeuwen; Danielle Meijer; Saskia Middeldorp; Laszlo A Groh; Michiel C Warlé
Journal:  Res Pract Thromb Haemost       Date:  2021-12-07
  2 in total

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