Literature DB >> 18475666

Lobenzarit disodium inhibits the constitutive NO-cGMP metabolic pathways. Possible involvement as an immunomodulatory drug.

J Padrón1, A Rojas, L Glaría, L Caveda, R Delgado, M Torres, O Martínez, E López, A Beltrán, M Palacios.   

Abstract

Lobenzarit disodtulIl (CCA) is a novel immunomodulatory drug useful in the treatment of chronic inflammations. Its principal mechanism of action seems to be through enhancing the T suppressor/T helper lymphocyte ratio. However, the molecular basis for these actions remains unclear. In this study it was found that CCA inhibits the production of guanosine 3',5'-cyclic monophosphate almost completely when present in concentrations of 1 mM. Further results demonstrated that such inhibition could also be explained by interference in constitutive nitric oxide generation. In addition to previous findings, more insight into the molecular mechanism of action of CCA is provided.

Entities:  

Year:  1995        PMID： 18475666      PMCID： PMC2365655          DOI： 10.1155/S0962935195000597

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN： 0962-9351            Impact factor:   4.711


  18 in total

1.  Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

Authors:  D S Bredt; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

2.  Kinetic characteristics of nitric oxide synthase from rat brain.

Authors:  R G Knowles; M Palacios; R M Palmer; S Moncada
Journal:  Biochem J       Date:  1990-07-01       Impact factor: 3.857

3.  Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

Authors:  D J Stuehr; H J Cho; N S Kwon; M F Weise; C F Nathan
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205

4.  Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.

Authors:  A M Leone; R M Palmer; R G Knowles; P L Francis; D S Ashton; S Moncada
Journal:  J Biol Chem       Date:  1991-12-15       Impact factor: 5.157

5.  Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine.

Authors:  C A Gruetter; B K Barry; D B McNamara; D Y Gruetter; P J Kadowitz; L Ignarro
Journal:  J Cyclic Nucleotide Res       Date:  1979

6.  Guanosine 3':5'-cyclic monophosphate: a possible intracellular mediator of mitogenic influences in lymphocytes.

Authors:  J W Hadden; E M Hadden; M K Haddox; N D Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1972-10       Impact factor: 11.205

7.  Nitric oxide and cyclic GMP formation induced by interleukin 1 beta in islets of Langerhans. Evidence for an effector role of nitric oxide in islet dysfunction.

Authors:  J A Corbett; J L Wang; J H Hughes; B A Wolf; M A Sweetland; J R Lancaster; M L McDaniel
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857

8.  Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge.

Authors:  M Palacios; J Padron; L Glaria; A Rojas; R Delgado; R Knowles; S Moncada
Journal:  Biochem Biophys Res Commun       Date:  1993-10-15       Impact factor: 3.575

9.  Interleukin 1 activates soluble guanylate cyclase in human vascular smooth muscle cells through a novel nitric oxide-independent pathway.

Authors:  D Beasley; M McGuiggin
Journal:  J Exp Med       Date:  1994-01-01       Impact factor: 14.307

10.  The influence of intracellular levels of cyclic nucleotides on cell proliferation and the induction of antibody synthesis.

Authors:  J Watson
Journal:  J Exp Med       Date:  1975-01-01       Impact factor: 14.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.