Literature DB >> 18475588

A comparison of the Antileukaemic Effects of Recombinant Human Tumour Necrosis Factor-alpha and its Muteins on Leukaemia L1210 and Leukaemia P388 in Mice.

K Warzocha1, J Góra-Tybor, M Kwinkowski, B Szymańska, T Robak.   

Abstract

We investigated the influence of recombinant human tumour necrosis factor alpha (TNF-alpha) and its derivatives termed muteins III, V, VI-in which the first 3 to 7 amino acids of native TNF-alpha have been replaced-on the survival time of mice inoculated with leukaemia L1210 or leukaemia P338. TNF-alpha prolonged the survival of mice with leukaemia L1210 but did not have any therapeutic activity in leukaemia P388-bearing mice. Muteins-treated mice with leukaemia P388 lived longer than animals receiving TNF-alpha, while those inoculated with leukaemia L1210 did not show any significant prolongation of life compared with the TNF-alpha treated group. The results presented in this report indicate that the antileukaemic activity of TNF-alpha is governed at least in part by the nature of the N-terminal amino acids.

Entities:  

Year:  1994        PMID： 18475588      PMCID： PMC2365583          DOI： 10.1155/S0962935194000578

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN： 0962-9351            Impact factor:   4.711


  20 in total

1.  Mutational analysis of structure--activity relationships in human tumor necrosis factor-alpha.

Authors:  J Yamagishi; H Kawashima; N Matsuo; M Ohue; M Yamayoshi; T Fukui; H Kotani; R Furuta; K Nakano; M Yamada
Journal:  Protein Eng       Date:  1990-08

2.  Tumor necrosis factor mediates autocrine growth inhibition in a chronic leukemia.

Authors:  A S Duncombe; H E Heslop; M Turner; A Meager; R Priest; T Exley; M K Brenner
Journal:  J Immunol       Date:  1989-12-01       Impact factor: 5.422

3.  Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein.

Authors:  P W Gray; K Barrett; D Chantry; M Turner; M Feldmann
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

4.  Antileukemic effects of recombinant human tumor necrosis factor alpha (rh-TNF alpha) with cyclophosphamide or methotrexate on leukemia L1210 and leukemia P388 in mice.

Authors:  K Warzocha; T Robak
Journal:  Acta Haematol Pol       Date:  1992

5.  Molecular cloning and expression of a receptor for human tumor necrosis factor.

Authors:  T J Schall; M Lewis; K J Koller; A Lee; G C Rice; G H Wong; T Gatanaga; G A Granger; R Lentz; H Raab
Journal:  Cell       Date:  1990-04-20       Impact factor: 41.582

6.  The influence of recombinant human tumor necrosis factor-alpha, alone and in combination with cyclophosphamide or methotrexate, on leukemia L1210 and normal hematopoiesis in mice.

Authors:  K Warzocha; T Robak; A Korycka; J Graczyk; W Pakulska; G Gałazka; J Kłysik
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  1991       Impact factor: 4.291

7.  The effects of tumor necrosis factor (TNF) derivatives on TNF receptors.

Authors:  H Tchorzewski; K Zeman; E Paleolog; F Brennan; M Feldmann; M Kahan; P Guga; M Kwinkowski; B Szymanska; J Jarosz
Journal:  Cytokine       Date:  1993-03       Impact factor: 3.861

8.  The role of amino functions in recombinant human tumor necrosis factor in expression of biological activity.

Authors:  T Utsumi; M C Hung; J Klostergaard
Journal:  Mol Immunol       Date:  1992-01       Impact factor: 4.407

9.  Synthesis and expression in E. coli of the gene for human tumor necrosis factor (h alpha TNF).

Authors:  J Kłysik; A Konarzewska-Zglińska; G Gałazka; B Uznański; A Okruszek; P Guga; A Wilk; M Koziołkiewicz; H Tchórzewski; M Zembala
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  1991       Impact factor: 4.291

10.  The effect of tumour necrosis factor-alpha (TNF-alpha) muteins on human neutrophils in vitro.

Authors:  H Tchorzewski; K Zeman; J Kantorski; E Paleolog; M Kahan; M Feldmann; M Kwinkowski; P Guga; B Szymanska; P Parniewski; A Wilk; J Jarosz
Journal:  Mediators Inflamm       Date:  1993       Impact factor: 4.711
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  1 in total

1.  The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-alpha or its mutein on murine leukaemias L1210 and P388.

Authors:  J Góra-Tybor; K Warzocha; T Robak
Journal:  Mediators Inflamm       Date:  1995       Impact factor: 4.711
  1 in total

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