Literature DB >> 18475476

Comparison of the C-mediating killing activity and C-activating properties of mouse monoclonal and polyclonal antibodies against Trypanosoma cruzi.

T L Kipnis1, D V Tambourgi, M J Alves, W D Silva.   

Abstract

A Mouse polyclonal antiserum against Trypanosoma cruzi or its IgG and IgM fractions and five monoclonal antibodies (two IgM, two IgG(1) and one IgG(2a)) recognize and combine with membrane components of trypomastigote forms of the parasite as revealed by immunofluorescence. Although all these antibodies sensitize trypomastigotes and prepare them to activate the complement (C) system, as measured by consumption of total C, C4, B and C3, only the polyclonal antiserum or its IgG, IgM and Fabmu fragments were able to induce trypanosome lysis by the alternative C pathway.

Entities:  

Year:  1992        PMID： 18475476      PMCID： PMC2365359          DOI： 10.1155/S0962935192000450

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN： 0962-9351            Impact factor:   4.711


  15 in total

1.  Transformation of Trypanosoma cruzi trypomastigote bloodstream forms by immune IgM and its Fab mu fragment into activators of the alternative complement pathway.

Authors:  T L Kipnis; M Sucupira; W D da Silva
Journal:  Braz J Med Biol Res       Date:  1987       Impact factor: 2.590

2.  Distribution of membrane cofactor protein of complement on human peripheral blood cells. An altered form is found on granulocytes.

Authors:  T Seya; L L Ballard; N S Bora; V Kumar; W Cui; J P Atkinson
Journal:  Eur J Immunol       Date:  1988-08       Impact factor: 5.532

3.  Biochemical characterization of a factor produced by trypomastigotes of Trypanosoma cruzi that accelerates the decay of complement C3 convertases.

Authors:  K A Joiner; W D daSilva; M T Rimoldi; C H Hammer; A Sher; T L Kipnis
Journal:  J Biol Chem       Date:  1988-08-15       Impact factor: 5.157

4.  Partial inhibition of trypomastigote entry into cultured mammalian cells by monoclonal antibodies against a surface glycoprotein of Trypanosoma cruzi.

Authors:  M J Alves; G Abuin; V Y Kuwajima; W Colli
Journal:  Mol Biochem Parasitol       Date:  1986-10       Impact factor: 1.759

5.  C4a: the third anaphylatoxin of the human complement system.

Authors:  J P Gorski; T E Hugli; H J Müller-Eberhard
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

6.  Effect of Trypanosoma cruzi membrane components on the formation of the classical pathway C3 convertase.

Authors:  T L Kipnis; D V Tambourgi; M Sucupira; W Dias-da-Silva
Journal:  Braz J Med Biol Res       Date:  1986       Impact factor: 2.590

7.  Developmentally regulated expression by Trypanosoma cruzi of molecules that accelerate the decay of complement C3 convertases.

Authors:  M T Rimoldi; A Sher; S Heiny; A Lituchy; C H Hammer; K Joiner
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

8.  Resistance against Trypanosoma cruzi associated to anti-living trypomastigote antibodies.

Authors:  A U Krettli; Z Brener
Journal:  J Immunol       Date:  1982-05       Impact factor: 5.422

9.  Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution.

Authors:  M K Pangburn; R D Schreiber; H J Müller-Eberhard
Journal:  J Exp Med       Date:  1977-07-01       Impact factor: 14.307

10.  Human C4-binding protein. II. Role in proteolysis of C4b by C3b-inactivator.

Authors:  T Fujita; I Gigli; V Nussenzweig
Journal:  J Exp Med       Date:  1978-10-01       Impact factor: 14.307
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  1 in total

1.  Inefficient complement system clearance of Trypanosoma cruzi metacyclic trypomastigotes enables resistant strains to invade eukaryotic cells.

Authors:  Igor Cestari; Marcel I Ramirez
Journal:  PLoS One       Date:  2010-03-16       Impact factor: 3.240
  1 in total

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