S A Nickisch1, L Izquierdo, M A Vill, L Curet, G C Wolf. 1. Divisions of Maternal Fetal Medicine and Reproductive Endocrinology Department of Obstetrics and Gynecology University of New Mexico School of Medicine, Albuquerque, NM, USA.
Abstract
BACKGROUND: Disseminated coccidiomycosis during pregnancy can lead to both maternal and neonatal mortality. Placentitis is an uncommon sequelae and its effect on placental function remains speculative. The present report describes our management of such a case and describes serial umbilical artery velocimetry of an affected placenta. CASE: A pregnant woman with coccidioidal placentitis confirmed histologically was treated with systemic and intrathecal amphotericin B starting at 28 weeks gestation. Serial umbilical artery velocimetry revealed that all systolic/diastolic ratios remained normal, and a normal infant was delivered at term. CONCLUSION: Coccidioidal placentitis was successfully treated with amphotericin B; serial umbilical artery velocimetry monitoring exhibited no abnormalities and, along with other reassuring fetal parameters, allowed continuation of the pregnancy to term.
BACKGROUND: Disseminated coccidiomycosis during pregnancy can lead to both maternal and neonatal mortality. Placentitis is an uncommon sequelae and its effect on placental function remains speculative. The present report describes our management of such a case and describes serial umbilical artery velocimetry of an affected placenta. CASE: A pregnant woman with coccidioidal placentitis confirmed histologically was treated with systemic and intrathecal amphotericin B starting at 28 weeks gestation. Serial umbilical artery velocimetry revealed that all systolic/diastolic ratios remained normal, and a normal infant was delivered at term. CONCLUSION:Coccidioidal placentitis was successfully treated with amphotericin B; serial umbilical artery velocimetry monitoring exhibited no abnormalities and, along with other reassuring fetal parameters, allowed continuation of the pregnancy to term.
Authors: J Ducey; H Schulman; G Farmakides; B Rochelson; L Bracero; A Fleischer; E Guzman; D Winter; B Penny Journal: Am J Obstet Gynecol Date: 1987-09 Impact factor: 8.661