Literature DB >> 1847480

Structure and expression of murine cytomegalovirus immediate-early gene 2.

M Messerle1, G M Keil, U H Koszinowski.   

Abstract

The immediate-early gene ie2 of murine cytomegalovirus was characterized. The 1.75-kb ie2 transcript is spliced from three exons, of 78, 124, and 1,283 nucleotides, which are separated by introns of 1,245 and 364 nucleotides. An ATG codon located in the third exon leads into an open reading frame of 391 codons. Immediate-early expression of the predicted polypeptide was confirmed by immunoprecipitation of a 43-kDa protein by using an antiserum raised against a bacterial fusion protein. The predicted IE2 amino acid sequence has regions with similarity to amino acid sequences of members of the human cytomegalovirus US22 family.

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Year:  1991        PMID： 1847480      PMCID： PMC239953     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  40 in total

1.  Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4.

Authors:  N A DeLuca; P A Schaffer
Journal:  Mol Cell Biol       Date:  1985-08       Impact factor: 4.272

2.  Improved tools for biological sequence comparison.

Authors:  W R Pearson; D J Lipman
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

3.  An immediate early gene of human cytomegalovirus encodes a potential membrane glycoprotein.

Authors:  T Kouzarides; A T Bankier; S C Satchwell; E Preddy; B G Barrell
Journal:  Virology       Date:  1988-07       Impact factor: 3.616

4.  Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.

Authors:  M Kozak
Journal:  Nucleic Acids Res       Date:  1984-01-25       Impact factor: 16.971

5.  Identification and characterization of the human cytomegalovirus immediate-early region 2 gene that stimulates gene expression from an inducible promoter.

Authors:  T W Hermiston; C L Malone; P R Witte; M F Stinski
Journal:  J Virol       Date:  1987-10       Impact factor: 5.103

6.  Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters.

Authors:  P O'Hare; G S Hayward
Journal:  J Virol       Date:  1985-03       Impact factor: 5.103

7.  A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus.

Authors:  M Boshart; F Weber; G Jahn; K Dorsch-Häsler; B Fleckenstein; W Schaffner
Journal:  Cell       Date:  1985-06       Impact factor: 41.582

8.  The 89,000-Mr murine cytomegalovirus immediate-early protein activates gene transcription.

Authors:  U H Koszinowski; G M Keil; H Volkmer; M R Fibi; A Ebeling-Keil; K Münch
Journal:  J Virol       Date:  1986-04       Impact factor: 5.103

9.  Insertional mutagenesis of the murine cytomegalovirus genome: one prominent alpha gene (ie2) is dispensable for growth.

Authors:  W C Manning; E S Mocarski
Journal:  Virology       Date:  1988-12       Impact factor: 3.616

10.  trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus.

Authors:  M C Pizzorno; P O'Hare; L Sha; R L LaFemina; G S Hayward
Journal:  J Virol       Date:  1988-04       Impact factor: 5.103
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  31 in total

1.  Identification of a boundary domain adjacent to the potent human cytomegalovirus enhancer that represses transcription of the divergent UL127 promoter.

Authors:  A Angulo; D Kerry; H Huang; E M Borst; A Razinsky; J Wu; U Hobom; M Messerle; P Ghazal
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

2.  Random, asynchronous, and asymmetric transcriptional activity of enhancer-flanking major immediate-early genes ie1/3 and ie2 during murine cytomegalovirus latency in the lungs.

Authors:  N K Grzimek; D Dreis; S Schmalz; M J Reddehase
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

3.  In vivo replication of recombinant murine cytomegalovirus driven by the paralogous major immediate-early promoter-enhancer of human cytomegalovirus.

Authors:  N K Grzimek; J Podlech; H P Steffens; R Holtappels; S Schmalz; M J Reddehase
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

4.  The major immediate-early gene ie3 of mouse cytomegalovirus is essential for viral growth.

Authors:  A Angulo; P Ghazal; M Messerle
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

5.  Enhancerless cytomegalovirus is capable of establishing a low-level maintenance infection in severely immunodeficient host tissues but fails in exponential growth.

Authors:  Jürgen Podlech; Rares Pintea; Kai A Kropp; Annette Fink; Niels A W Lemmermann; Katja C Erlach; Elena Isern; Ana Angulo; Peter Ghazal; Matthias J Reddehase
Journal:  J Virol       Date:  2010-04-07       Impact factor: 5.103

6.  The class II membrane glycoprotein G of bovine respiratory syncytial virus, expressed from a synthetic open reading frame, is incorporated into virions of recombinant bovine herpesvirus 1.

Authors:  G Kühnle; A Heinze; J Schmitt; K Giesow; G Taylor; I Morrison; F A Rijsewijk; J T van Oirschot; G M Keil
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

Review 7.  Viral latency drives 'memory inflation': a unifying hypothesis linking two hallmarks of cytomegalovirus infection.

Authors:  Christof K Seckert; Marion Griessl; Julia K Büttner; Sabine Scheller; Christian O Simon; Kai A Kropp; Angélique Renzaho; Birgit Kühnapfel; Natascha K A Grzimek; Matthias J Reddehase
Journal:  Med Microbiol Immunol       Date:  2012-09-19       Impact factor: 3.402

8.  Frequent coinfection of cells explains functional in vivo complementation between cytomegalovirus variants in the multiply infected host.

Authors:  Luka Cicin-Sain; Jürgen Podlech; Martin Messerle; Matthias J Reddehase; Ulrich H Koszinowski
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103

9.  Murine cytomegalovirus major immediate-early enhancer region operating as a genetic switch in bidirectional gene pair transcription.

Authors:  Christian O Simon; Birgit Kühnapfel; Matthias J Reddehase; Natascha K A Grzimek
Journal:  J Virol       Date:  2007-05-09       Impact factor: 5.103

10.  Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus.

Authors:  C A Stoddart; R D Cardin; J M Boname; W C Manning; G B Abenes; E S Mocarski
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103
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