| Literature DB >> 1847426 |
D L Flynn1, T R Belliotti, A M Boctor, D T Connor, C R Kostlan, D E Nies, D F Ortwine, D J Schrier, J C Sircar.
Abstract
A series of styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles were prepared and found to be dual inhibitors of 5-lipoxygenase and cyclooxygenase in rat basophilic leukemia cells. Compounds from this series also were found to inhibit the in vivo production of LTB4 when dosed orally in rats. Among these compounds, di-tert-butylphenols 19 and 33 exhibit oral activity in various models of inflammation and, most importantly, are devoid of ulcerogenic potential.Entities:
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Year: 1991 PMID： 1847426 DOI： 10.1021/jm00106a006
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446