| Literature DB >> 18474236 |
Marjolaine Roche1, Philippe Rondeau, Nihar Ranjan Singh, Evelyne Tarnus, Emmanuel Bourdon.
Abstract
Free radicals are a normal component of cellular oxygen metabolism in mammals. However, free radical-associated damage is an important factor in many pathological processes. Glycation and oxidative damage cause protein modifications, frequently observed in numerous diseases. Albumin represents a very abundant and important circulating antioxidant. This review brings together recent insights on albumin antioxidant properties. First, it focuses on the different activities of albumin concerning protein antioxidation. In particular, we describe the role of albumin in ligand binding and free radical-trapping activities. In addition, physiological and pathological situations that modify the antioxidant properties of albumin are reported.Entities:
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Year: 2008 PMID: 18474236 DOI: 10.1016/j.febslet.2008.04.057
Source DB: PubMed Journal: FEBS Lett ISSN: 0014-5793 Impact factor: 4.124