New aspects of the relationship among hypertension, obesity, and the kidneys.

Recent studies have highlighted the association between obesity and chronic renal disease. Overweight has been shown to be a survival advantage in patients on maintenance hemodialysis therapy. However, in patients with preterminal renal failure, obesity may contribute to the progression of renal disease. Data collected from the Prevention of Renal and Vascular End-stage Disease study suggest that changes in weight directly influence albuminuria, hinting that albumin excretion could be used in the general population as a surrogate marker for risk of developing chronic kidney disease. The causal pathways linking excess weight to chronic kidney disease and hypertension are briefly reviewed in this article, and therapeutic approaches to combat this growing health problem are highlighted.