Literature DB >> 18473783

HIV Nef: role in pathogenesis and viral fitness.

Kevin K Ariën1, Bruno Verhasselt.   

Abstract

Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity, influences the trafficking of a large number of surface receptors and interferes with TCR signalling, consequently modulating T-cell activation. In vivo observations with Long Term Non-Progressors harbouring a Nef-defective HIV and vaccination studies with Nef-deleted SIV in Rhesus macaques have shown a prominent role for Nef in lentiviral pathogenesis. Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness.

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Year:  2008        PMID： 18473783     DOI： 10.2174/157016208784325001

Source DB:  PubMed          Journal:  Curr HIV Res        ISSN： 1570-162X            Impact factor:   1.581


  24 in total

1.  Counteraction of HLA-C-mediated immune control of HIV-1 by Nef.

Authors:  Anke Specht; Amalio Telenti; Raquel Martinez; Jacques Fellay; Elizabeth Bailes; David T Evans; Mary Carrington; Beatrice H Hahn; David B Goldstein; Frank Kirchhoff
Journal:  J Virol       Date:  2010-05-12       Impact factor: 5.103

2.  The human immunodeficiency virus type 1 Nef and Vpu proteins downregulate the natural killer cell-activating ligand PVR.

Authors:  Giulia Matusali; Marina Potestà; Angela Santoni; Cristina Cerboni; Margherita Doria
Journal:  J Virol       Date:  2012-02-01       Impact factor: 5.103

3.  Replication Capacity of Viruses from Acute Infection Drives HIV-1 Disease Progression.

Authors:  Philippe Selhorst; Carina Combrinck; Nonkululeko Ndabambi; Sherazaan D Ismail; Melissa-Rose Abrahams; Miguel Lacerda; Natasha Samsunder; Nigel Garrett; Quarraisha Abdool Karim; Salim S Abdool Karim; Carolyn Williamson
Journal:  J Virol       Date:  2017-03-29       Impact factor: 5.103

Review 4.  Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution?

Authors:  Frank Kirchhoff
Journal:  Nat Rev Microbiol       Date:  2009-03-23       Impact factor: 60.633

5.  Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins.

Authors:  Anke Heigele; Michael Schindler; Clement W Gnanadurai; Jolie A Leonard; Kathleen L Collins; Frank Kirchhoff
Journal:  J Virol       Date:  2011-10-19       Impact factor: 5.103

6.  A Novel HIV-1 Nef Mutation in a Primary Pediatric Isolate Impairs MHC-Class I Downregulation and Cytopathicity.

Authors:  Ayub Ali; Robert L Furler; Livia Pedroza-Martins; Arnaud D Colantonio; Deborah Anisman-Posner; Yvonne Bryson; Otto O Yang; Christel H Uittenbogaart
Journal:  AIDS Res Hum Retroviruses       Date:  2019-11-04       Impact factor: 2.205

7.  Single vector system for efficient N-myristoylation of recombinant proteins in E. coli.

Authors:  Julian M Glück; Silke Hoffmann; Bernd W Koenig; Dieter Willbold
Journal:  PLoS One       Date:  2010-04-09       Impact factor: 3.240

8.  Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments.

Authors:  Walter M Kim; Alexander B Sigalov; Lawrence J Stern
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2010-01-22

9.  The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.

Authors:  Nathalie Arhel; Martin Lehmann; Karen Clauss; G Ulrich Nienhaus; Vincent Piguet; Frank Kirchhoff
Journal:  J Clin Invest       Date:  2009-09-14       Impact factor: 14.808

10.  Nef gene evolution from a single transmitted strain in acute SIV infection.

Authors:  Benjamin N Bimber; Pauline Chugh; Elena E Giorgi; Baek Kim; Anthony L Almudevar; Stephen Dewhurst; David H O'Connor; Ha Youn Lee
Journal:  Retrovirology       Date:  2009-06-08       Impact factor: 4.602
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