BACKGROUND: About 40% of patients with stroke will develop depression at some stage after the acute event. Post-stroke depression (PSD) is associated with a poor prognosis. Depressed patients have more severe deficits in activities of daily living, a worse functional outcome, more severe cognitive deficits and increased mortality as compared to stroke patients without depression. OBJECTIVE: This review will focus on available controlled trials of treatment for PSD. METHODS: An unsystematic review of recent studies for the treatment of PSD. RESULTS: Randomized controlled trials have demonstrated the efficacy of sertraline, citalopram and nortriptyline to treat post-stroke depression. Whether antidepressant medication may help to prevent post-stroke depression and decrease post-stroke mortality will require further controlled studies.
BACKGROUND: About 40% of patients with stroke will develop depression at some stage after the acute event. Post-stroke depression (PSD) is associated with a poor prognosis. Depressedpatients have more severe deficits in activities of daily living, a worse functional outcome, more severe cognitive deficits and increased mortality as compared to strokepatients without depression. OBJECTIVE: This review will focus on available controlled trials of treatment for PSD. METHODS: An unsystematic review of recent studies for the treatment of PSD. RESULTS: Randomized controlled trials have demonstrated the efficacy of sertraline, citalopram and nortriptyline to treat post-stroke depression. Whether antidepressant medication may help to prevent post-stroke depression and decrease post-stroke mortality will require further controlled studies.
Authors: George S Alexopoulos; Christopher F Murphy; Faith M Gunning-Dixon; Charles E Glatt; Vassilios Latoussakis; Robert E Kelly; Dora Kanellopoulos; Sibel Klimstra; Kelvin O Lim; Robert C Young; Matthew J Hoptman Journal: J Affect Disord Date: 2009-04-17 Impact factor: 4.839
Authors: Yejin Lee; Brian Chen; Mandy W M Fong; Jin-Moo Lee; Ginger E Nicol; Eric J Lenze; Lisa T Connor; Carolyn Baum; Alex W K Wong Journal: Top Stroke Rehabil Date: 2020-08-12 Impact factor: 2.119
Authors: Yu-Zhi Shi; Yu-Tao Xiang; Shuo-Lin Wu; Ning Zhang; Juan Zhou; Ying Bai; Shuo Wang; Yi-Long Wang; Xing-Quan Zhao; Gabor S Ungvari; Helen F K Chiu; Yong-Jun Wang; Chun-Xue Wang Journal: PLoS One Date: 2014-07-08 Impact factor: 3.240
Authors: Sui-Cheung Man; Ben H B Hung; Roger M K Ng; Xiao-Chun Yu; Hobby Cheung; Mandy P M Fung; Leonard S W Li; Kwok-Pui Leung; Kei-Pui Leung; Kevin W Y Tsang; Eric Ziea; Vivian T Wong; Zhang-Jin Zhang Journal: BMC Complement Altern Med Date: 2014-07-19 Impact factor: 3.659