Literature DB >> 18473076

Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases.

Yoshio Hayashi1, Thomas Regnier, Shigenobu Nishiguchi, Magne O Sydnes, Daisuke Hashimoto, Junya Hasegawa, Takahiro Katoh, Tetsuya Kajimoto, Masataka Shiozuka, Ryoichi Matsuda, Manabu Node, Yoshiaki Kiso.   

Abstract

Herein, we describe an efficient strategy for the total synthesis of (+)-negamycin using commercially available achiral N-Boc-2-aminoacetaldehyde as starting material with 42% overall yield for a limited number of steps.

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Year:  2008        PMID: 18473076     DOI: 10.1039/b801498a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  3 in total

Review 1.  Chemotherapeutics overcoming nonsense mutation-associated genetic diseases: medicinal chemistry of negamycin.

Authors:  Akihiro Taguchi; Keisuke Hamada; Yoshio Hayashi
Journal:  J Antibiot (Tokyo)       Date:  2017-09-27       Impact factor: 2.649

2.  Structure-Activity Relationship Studies of 3-epi-Deoxynegamycin Derivatives as Potent Readthrough Drug Candidates.

Authors:  Keisuke Hamada; Akihiro Taguchi; Masaya Kotake; Suguru Aita; Saori Murakami; Kentaro Takayama; Fumika Yakushiji; Yoshio Hayashi
Journal:  ACS Med Chem Lett       Date:  2015-05-11       Impact factor: 4.345

3.  Negamycin analogue with readthrough-promoting activity as a potential drug candidate for duchenne muscular dystrophy.

Authors:  Akihiro Taguchi; Shigenobu Nishiguchi; Masataka Shiozuka; Takao Nomoto; Mayuko Ina; Shouta Nojima; Ryoichi Matsuda; Yoshiaki Nonomura; Yoshiaki Kiso; Yuri Yamazaki; Fumika Yakushiji; Yoshio Hayashi
Journal:  ACS Med Chem Lett       Date:  2012-01-02       Impact factor: 4.345

  3 in total

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