Literature DB >> 18472924

Interleukin-5 potentiates sulfidopeptide leukotriene production by human eosinophils.

A J Van Oosterhout1, A Van Der Poel, L Koenderman, D Roos, F P Nijkamp.   

Abstract

Interleukin-5 (IL-5) has been shown to be a selective eosinophil growth and differentiation factor. In the present study, the effect of recombinant human IL-5 on human eosinophil sulfidopeptide leukotriene production was investigated. IL-5 did not affect leukotriene synthesis in unstimulated eosinophils. However, IL-5 potentiated leukotriene synthesis by eosinophils stimulated with serum treated zymosan (STZ) or the calcium ionophore A23187 by 69% and 135%, respectively. The priming effect of IL-5 was dose dependent, with significant stimulation occurring at 1 000 U/ml for STZ and 100-1 000 U/ml for A23187. Pre-incubation with IL-5 did not increase leukotriene synthesis further.

Entities:  

Year:  1994        PMID： 18472924      PMCID： PMC2367018          DOI： 10.1155/S0962935194000098

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN： 0962-9351            Impact factor:   4.711


  19 in total

1.  Enhancement of human eosinophil cytotoxicity and leukotriene synthesis by biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor.

Authors:  D S Silberstein; W F Owen; J C Gasson; J F DiPersio; D W Golde; J C Bina; R Soberman; K F Austen; J R David
Journal:  J Immunol       Date:  1986-11-15       Impact factor: 5.422

Review 2.  The eosinophil and bronchial asthma: current understanding.

Authors:  G J Gleich
Journal:  J Allergy Clin Immunol       Date:  1990-02       Impact factor: 10.793

3.  IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner.

Authors:  G M Walsh; A Hartnell; A J Wardlaw; K Kurihara; C J Sanderson; A B Kay
Journal:  Immunology       Date:  1990-10       Impact factor: 7.397

4.  Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium.

Authors:  E Frigas; D A Loegering; G J Gleich
Journal:  Lab Invest       Date:  1980-01       Impact factor: 5.662

5.  The effect of human eosinophil granule major basic protein on airway responsiveness in the rat in vivo. A comparison with polycations.

Authors:  D A Uchida; S J Ackerman; A J Coyle; G L Larsen; P F Weller; J Freed; C G Irvin
Journal:  Am Rev Respir Dis       Date:  1993-04

6.  Recombinant interleukin-5 induces in vivo airway hyperresponsiveness to histamine in guinea pigs.

Authors:  A J Van Oosterhout; I Van Ark; G Hofman; H F Savelkoul; F P Nijkamp
Journal:  Eur J Pharmacol       Date:  1993-06-04       Impact factor: 4.432

7.  Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma.

Authors:  D S Robinson; Q Hamid; S Ying; A Tsicopoulos; J Barkans; A M Bentley; C Corrigan; S R Durham; A B Kay
Journal:  N Engl J Med       Date:  1992-01-30       Impact factor: 91.245

8.  Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro.

Authors:  S Motojima; E Frigas; D A Loegering; G J Gleich
Journal:  Am Rev Respir Dis       Date:  1989-03

9.  Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs.

Authors:  A J Van Oosterhout; A R Ladenius; H F Savelkoul; I Van Ark; K C Delsman; F P Nijkamp
Journal:  Am Rev Respir Dis       Date:  1993-03

10.  Aerosolized leukotriene D4 converts monkeys that are negative aerosolized ascaris responders to positive airway responders.

Authors:  R Patterson; K E Harris; P R Bernstein; R D Krell
Journal:  Life Sci       Date:  1986-03-31       Impact factor: 5.037
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