Literature DB >> 18472909

Hormone anchored metal complexes. 1. Synthesis, structure, spectroscopy and in vitro antitumor activity of testosterone acetate thiosemicarbazone and its metal complexes.

A Murugkar1, B Unnikrishnan, S Padhye, R Bhonde, S Teat, E Triantafillou, E Sinn.   

Abstract

Testosterone acetate thiosemicarbazone (TATSC, 17-beta-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl(1)] followed by [Cu(TATSC)Cl(2)] and the ligand in compariosn with cisplatin.

Entities:  

Year:  1999        PMID： 18472909      PMCID： PMC2366831          DOI： 10.1155/MBD.1999.177

Source DB:  PubMed          Journal:  Met Based Drugs        ISSN： 0793-0291


  4 in total

1.  DNA binding, antioxidant, cytotoxicity (MTT, lactate dehydrogenase, NO), and cellular uptake studies of structurally different nickel(II) thiosemicarbazone complexes: synthesis, spectroscopy, electrochemistry, and X-ray crystallography.

Authors:  R Prabhakaran; P Kalaivani; R Huang; P Poornima; V Vijaya Padma; F Dallemer; K Natarajan
Journal:  J Biol Inorg Chem       Date:  2012-12-29       Impact factor: 3.358

2.  Cytotoxicity in human cancer cells and mitochondrial dysfunction induced by a series of new copper(I) complexes containing tris(2-cyanoethyl)phosphines.

Authors:  Alessandro Zanella; Valentina Gandin; Marina Porchia; Fiorenzo Refosco; Francesco Tisato; Francesca Sorrentino; Guido Scutari; Maria Pia Rigobello; Cristina Marzano
Journal:  Invest New Drugs       Date:  2010-06-22       Impact factor: 3.850

3.  Pyridyl thiosemicarbazide: synthesis, crystal structure, DFT/B3LYP, molecular docking studies and its biological investigations.

Authors:  Sraa Abu-Melha
Journal:  Chem Cent J       Date:  2018-09-29       Impact factor: 4.215

4.  Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes.

Authors:  Yanmin Huang; Erbin Kong; Chunfang Gan; Zhiping Liu; Qifu Lin; Jianguo Cui
Journal:  Bioinorg Chem Appl       Date:  2015-10-08       Impact factor: 7.778
  4 in total

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