Literature DB >> 18472305

Methods for purifying and detoxifying sodium dodecyl sulfate-stabilized polyacrylate nanoparticles.

Julio C Garay-Jimenez1, Ashley Young, Danielle Gergeres, Kerriann Greenhalgh, Edward Turos.   

Abstract

Recent research in our laboratory has centered on studies of polyacrylate and polyacrylamide nanoparticle emulsions for use in antibiotic delivery. Our goal is to develop these nanoparticle emulsions for treatment of life-threatening bacterial infections such as those caused by methicillin-resistant Staphylococcus aureus. For this intended application it is necessary to ensure that the biological activity of the emulsion is due only to the drug attached to the polymeric chain and not to any extraneous components. To investigate this we evaluated cytotoxicity and microbiological activity of the nanoparticle emulsions before and after purification by centrifugation, dialysis, and gel filtration. Depending on the amount of surfactant used, all or most of the microbial and cellular toxicity can be removed by a simple purification procedure.

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Year:  2008        PMID： 18472305      PMCID： PMC2580797          DOI： 10.1016/j.nano.2008.03.004

Source DB:  PubMed          Journal:  Nanomedicine        ISSN： 1549-9634            Impact factor:   5.307


  21 in total

1.  Cytokine release and cytotoxicity in human keratinocytes and fibroblasts induced by phenols and sodium dodecyl sulfate.

Authors:  C S Newby; R M Barr; M W Greaves; A I Mallet
Journal:  J Invest Dermatol       Date:  2000-08       Impact factor: 8.551

2.  Trends in antimicrobial drug development: implications for the future.

Authors:  Brad Spellberg; John H Powers; Eric P Brass; Loren G Miller; John E Edwards
Journal:  Clin Infect Dis       Date:  2004-04-14       Impact factor: 9.079

3.  Comparison of diafiltration and tangential flow filtration for purification of nanoparticle suspensions.

Authors:  Gautam Dalwadi; Heather A E Benson; Yan Chen
Journal:  Pharm Res       Date:  2005-12       Impact factor: 4.200

4.  Variations in the mRNA expression of inflammatory mediators, markers of differentiation and lipid-metabolizing enzymes caused by sodium lauryl sulphate in cultured human keratinocytes.

Authors:  Hans Törmä; Sophia Geijer; Therése Gester; Karin Alpholm; Berit Berne; Magnus Lindberg
Journal:  Toxicol In Vitro       Date:  2005-11-07       Impact factor: 3.500

5.  Sodium lauryl sulfate and triclosan: in vitro cytotoxicity studies with gingival cells.

Authors:  H Babich; J P Babich
Journal:  Toxicol Lett       Date:  1997-05-16       Impact factor: 4.372

6.  Cytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactant.

Authors:  R H Müller; D Rühl; S Runge; K Schulze-Forster; W Mehnert
Journal:  Pharm Res       Date:  1997-04       Impact factor: 4.200

7.  Induction of proliferation of growth-inhibited keratinocytes and fibroblasts in monolayer culture by sodium lauryl sulfate: comparison with all-trans retinoic acid.

Authors:  J Varani; A Astrom; C E Griffiths; J J Voorhees
Journal:  J Invest Dermatol       Date:  1991-11       Impact factor: 8.551

8.  Penicillin-bound polyacrylate nanoparticles: restoring the activity of beta-lactam antibiotics against MRSA.

Authors:  Edward Turos; G Suresh Kumar Reddy; Kerriann Greenhalgh; Praveen Ramaraju; Sampath C Abeylath; Seyoung Jang; Sonja Dickey; Daniel V Lim
Journal:  Bioorg Med Chem Lett       Date:  2007-03-27       Impact factor: 2.823

Review 9.  Antimicrobial resistance determinants and future control.

Authors:  Stephan Harbarth; Matthew H Samore
Journal:  Emerg Infect Dis       Date:  2005-06       Impact factor: 6.883

Review 10.  An emptying quiver: antimicrobial drugs and resistance.

Authors:  J Todd Weber; Patrice Courvalin
Journal:  Emerg Infect Dis       Date:  2005-06       Impact factor: 6.883
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  4 in total

1.  Co-delivery of Sildenafil (Viagra(®)) and Crizotinib for synergistic and improved anti-tumoral therapy.

Authors:  João G Marques; Vítor M Gaspar; David Markl; Elisabete C Costa; Eugénia Gallardo; Ilídio J Correia
Journal:  Pharm Res       Date:  2014-03-13       Impact factor: 4.200

Review 2.  Anti-Methicillin-Resistant Staphylococcus aureus Nanoantibiotics.

Authors:  Raphaël Labruère; A J Sona; Edward Turos
Journal:  Front Pharmacol       Date:  2019-10-04       Impact factor: 5.810

3.  Physical properties and biological activity of poly(butyl acrylate-styrene) nanoparticle emulsions prepared with conventional and polymerizable surfactants.

Authors:  Julio C Garay-Jimenez; Danielle Gergeres; Ashley Young; Daniel V Lim; Edward Turos
Journal:  Nanomedicine       Date:  2009-02-13       Impact factor: 5.307

4.  Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies.

Authors:  Lucía Martín-Banderas; Josefa Alvarez-Fuentes; Matilde Durán-Lobato; José Prados; Consolación Melguizo; Mercedes Fernández-Arévalo; Maria Ángeles Holgado
Journal:  Int J Nanomedicine       Date:  2012-11-23
  4 in total

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