| Literature DB >> 18472006 |
Tamás Kardon1, Silvia Senesi, Paola Marcolongo, Balázs Legeza, Gábor Bánhegyi, József Mandl, Rosella Fulceri, Angelo Benedetti.
Abstract
The present study demonstrates the expression of hexose-6-phosphate dehydrogenase and 11 beta-hydroxysteroid dehydrogenase type 1 in human neutrophils, and the presence and activity of these enzymes in the microsomal fraction of the cells. Their concerted action together with the previously described glucose-6-phosphate transporter is responsible for cortisone-cortisol interconversion detected in human neutrophils. Furthermore, the results suggest that luminal NADPH generation by the cortisol dehydrogenase activity of 11 beta-hydroxysteroid dehydrogenase type 1 prevents neutrophil apoptosis provoked by the inhibition of the glucose-6-phosphate transporter. In conclusion, the maintenance of the luminal NADPH pool is an important antiapoptotic factor in neutrophil granulocytes.Entities:
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Year: 2008 PMID： 18472006 DOI： 10.1016/j.febslet.2008.04.045
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124