| Literature DB >> 18471840 |
Olof Hertting1, Milan Chromek, Zuzana Slamová, Lavinia Kádas, Maja Söderkvist, Inga Vainumäe, Tiina Tallvik, Stefan H Jacobson, Annelie Brauner.
Abstract
Cytotoxic necrotizing factor 1 (CNF1) is a well-defined virulence factor of uropathogenic Escherichia coli. We studied the role of CNF1 in uroepithelial cells as well as in children and adults with sporadic and recurrent UTI. Our study suggests that CNF1 may promote bacterial attachment and invasion and can induce an inflammatory response in the urinary tract in vitro but that its role in vivo is possibly minor in comparison with other virulence factors of the uropathogenic E. coli.Entities:
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Year: 2008 PMID： 18471840 DOI： 10.1016/j.toxicon.2008.03.019
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033