OBJECTIVE: To determine accuracy of procalcitonin concentrations for diagnosing nosocomial infections in critically ill neonates. DESIGN: Case-control study. SETTING: Neonatal intensive care unit of a teaching hospital. PATIENTS: Twenty-three neonates with nosocomial infection. Four controls matched for duration of hospital stay and birth date were chosen for each case patient. MEASUREMENTS AND RESULTS: PCT concentrations were measured by the LUMItest procalcitonin kit at onset of signs of infection and after recovery. Range of PCT concentrations (ng/ml) was 2.0 to 249.1 in case patients and 0.08 to 1.0 in controls (sensitivity and specificity, 100%). PCT values returned to normal (<1.0 ng/ml) by day 3 to 7 of appropriate antibiotic therapy. CONCLUSIONS: Measurement of PCT concentrations may be useful for early diagnosis and monitoring of infectious complications in neonates during their stay in the neonatal intensive care unit.
OBJECTIVE: To determine accuracy of procalcitonin concentrations for diagnosing nosocomial infections in critically ill neonates. DESIGN: Case-control study. SETTING: Neonatal intensive care unit of a teaching hospital. PATIENTS: Twenty-three neonates with nosocomial infection. Four controls matched for duration of hospital stay and birth date were chosen for each case patient. MEASUREMENTS AND RESULTS:PCT concentrations were measured by the LUMItest procalcitonin kit at onset of signs of infection and after recovery. Range of PCT concentrations (ng/ml) was 2.0 to 249.1 in case patients and 0.08 to 1.0 in controls (sensitivity and specificity, 100%). PCT values returned to normal (<1.0 ng/ml) by day 3 to 7 of appropriate antibiotic therapy. CONCLUSIONS: Measurement of PCT concentrations may be useful for early diagnosis and monitoring of infectious complications in neonates during their stay in the neonatal intensive care unit.
Authors: José B López Sastre; David Pérez Solís; Vicente Roqués Serradilla; Belén Fernández Colomer; Gil D Coto Cotallo; Xavier Krauel Vidal; Eduardo Narbona López; Manuel García del Río; Manuel Sánchez Luna; Antonio Belaustegui Cueto; Manuel Moro Serrano; Alfonso Urbón Artero; Emilio Alvaro Iglesias; Angel Cotero Lavín; Eduardo Martínez Vilalta; Bartolomé Jiménez Cobos Journal: BMC Pediatr Date: 2006-05-18 Impact factor: 2.125
Authors: Laurence Dillenseger; Claire Langlet; Silvia Iacobelli; Thomas Lavaux; Charline Ratomponirina; Marc Labenne; Dominique Astruc; François Severac; Jean Bernard Gouyon; Pierre Kuhn Journal: Front Pediatr Date: 2018-11-13 Impact factor: 3.418