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Literature DB >> 18469805

Extra centrosomes and/or chromosomes prolong mitosis in human cells.

Zhenye Yang¹, Jadranka Loncarek, Alexey Khodjakov, Conly L Rieder.

Abstract

Using laser microsurgery and cell fusion we have explored how additional centrosomes and/or chromosomes influence the duration of mitosis in human cells. We found that doubling the chromosome number added approximately 10 min to a 20 min division, whereas doubling the number of centrosomes added approximately 30 min more. Extra centrosomes and/or chromosomes prolong mitosis by delaying satisfaction of the spindle assembly checkpoint. Thus mitosis can be prolonged by non-genetic means and extra chromosomes and centrosomes probably contribute to the elevated mitotic index seen in many tumours.

Entities: Disease Species

Mesh：

Year: 2008 PMID： 18469805 PMCID： PMC2430725 DOI： 10.1038/ncb1738

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

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