Literature DB >> 1846955

The amino acid (157-197) peptide segment of bovine leukemia virus p34tax encompass a leucine-rich globally neutral activation domain.

L Willems1, R Kettmann, A Burny.   

Abstract

The specific DNA-binding Gal4 amino-terminal portion (amino acids 1 to 147) was fused to protein segments of BLV transactivator p34tax and tested for its capacity to activate CAT-gene expression in mammalian cells. The p34tax peptide segment 157 to 197 encompasses an activating region. The segment is approximately located in the middle of p34tax and is globally neutral (net charge zero). The tax (157-197) domain contains 24% of leucine residues, possibly involved in heterologous protein interactions.

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Year:  1991        PMID： 1846955

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  11 in total

1.  Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo.

Authors:  J C Twizere; P Kerkhofs; A Burny; D Portetelle; R Kettmann; L Willems
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

2.  Mutations in the bovine leukemia virus Tax protein can abrogate the long terminal repeat-directed transactivating activity without concomitant loss of transforming potential.

Authors:  L Willems; C Grimonpont; H Heremans; N Rebeyrotte; G Chen; D Portetelle; A Burny; R Kettmann
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

3.  Tax & rex: overlapping genes of the Deltaretrovirus group.

Authors:  Kathleen Margaret McGirr; Gertrude Case Buehuring
Journal:  Virus Genes       Date:  2006-06       Impact factor: 2.332

4.  Serum response factor has functional roles both in indirect binding to the CArG box and in the transcriptional activation function of human T-cell leukemia virus type I Tax.

Authors:  M Fujii; H Tsuchiya; T Chuhjo; T Minamino; K Miyamoto; M Seiki
Journal:  J Virol       Date:  1994-11       Impact factor: 5.103

5.  The region between amino acids 245 and 265 of the bovine leukemia virus (BLV) tax protein restricts transactivation not only via the BLV enhancer but also via other retrovirus enhancers.

Authors:  S Tajima; Y Aida
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

6.  In vivo rescue of a silent tax-deficient bovine leukemia virus from a tumor-derived ovine B-cell line by recombination with a retrovirally transduced wild-type tax gene.

Authors:  A Van Den Broeke; C Bagnis; M Ciesiolka; Y Cleuter; H Gelderblom; P Kerkhofs; P Griebel; P Mannoni; A Burny
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103

7.  In vivo infection of sheep by bovine leukemia virus mutants.

Authors:  L Willems; R Kettmann; F Dequiedt; D Portetelle; V Vonèche; I Cornil; P Kerkhofs; A Burny; M Mammerickx
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

8.  A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis.

Authors:  Meripet Polat; Shin-Nosuke Takeshima; Kazuyoshi Hosomichi; Jiyun Kim; Taku Miyasaka; Kazunori Yamada; Mariluz Arainga; Tomoyuki Murakami; Yuki Matsumoto; Veronica de la Barra Diaz; Carlos Javier Panei; Ester Teresa González; Misao Kanemaki; Misao Onuma; Guillermo Giovambattista; Yoko Aida
Journal:  Retrovirology       Date:  2016-01-12       Impact factor: 4.602

9.  A detailed molecular analysis of complete bovine leukemia virus genomes isolated from B-cell lymphosarcomas.

Authors:  Gonzalo Moratorio; Sabrina Fischer; Sergio Bianchi; Lorena Tomé; Gonzalo Rama; Gonzalo Obal; Federico Carrión; Otto Pritsch; Juan Cristina
Journal:  Vet Res       Date:  2013-03-18       Impact factor: 3.683

Review 10.  Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human.

Authors:  Nicolas Gillet; Arnaud Florins; Mathieu Boxus; Catherine Burteau; Annamaria Nigro; Fabian Vandermeers; Hervé Balon; Amel-Baya Bouzar; Julien Defoiche; Arsène Burny; Michal Reichert; Richard Kettmann; Luc Willems
Journal:  Retrovirology       Date:  2007-03-16       Impact factor: 4.602
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